Actively Recruiting
Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy
Led by Second Affiliated Hospital, School of Medicine, Zhejiang University · Updated on 2025-12-19
330
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand the long-term outlook of coronary microvascular dysfunction in patients who have dilated cardiomyopathy. The main question being studied is whether coronary microvascular dysfunction affects health outcomes in these patients. The study is observational and sponsored by the Second Affiliated Hospital, School of Medicine, Zhejiang University. Participants will undergo coronary angiography to confirm the absence of significant blockages in the major coronary arteries. Angio-IMR, a measurement derived from the angiography, will be used to assess coronary microvascular function. The study groups include patients with and without coronary microvascular dysfunction, classified based on angiography results. During the study, participants will be followed for up to 5 years to monitor major adverse cardiac events. Researchers will collect clinical data and evaluate heart function using echocardiography and blood markers such as BNP or NT-proBNP. The study involves regular assessments to track heart health and the impact of microvascular dysfunction over time.
CONDITIONS
Brief Title
Prognostic Values of Coronary Microvascular Dysfunction in Patients With Dilated Cardiomyopathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosis of dilated cardiomyopathy confirmed by echocardiography with left ventricular end-diastolic diameter over 55 mm in men or over 50 mm in women
- Clinical signs and symptoms of congestive heart failure with BNP ≥ 35 pg/mL or NT-proBNP ≥ 125 pg/mL
- Left ventricular ejection fraction less than 45%
- Coronary angiography showing stenosis 50% or less in all major epicardial vessels
You will not qualify if you...
- Presence of coronary artery disease
- Hypertensive heart disease
- Rheumatic valvular heart disease
- Myocarditis
- Other secondary cardiomyopathies
- Poor quality coronary angiographic images
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo coronary angiography to confirm the absence of significant coronary stenosis and to calculate Angio-IMR.
1 visit (in-person)
Duration - 5 years
Participants are followed for major adverse cardiac events over a 5-year period after diagnostic evaluation.
Periodic visits during follow-up
Trial Site Locations
Total: 1 location
1
The second affiliated hospital of Zhejiang University School of Medicine
Hangzhou, Zhejiang, China, 310009
Actively Recruiting
Research Team
J
Jun Jiang, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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