Actively Recruiting
The Application of T1 Mapping in Real-World
Led by Chinese Academy of Medical Sciences, Fuwai Hospital · Updated on 2026-01-21
2000
Participants Needed
1
Research Sites
352 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions. We aim to establish reference values for how heart tissue characteristics vary in various diseases, which will help doctors better interpret these advanced MRI measurements in clinical practice. The main questions it aims to answer are: What are the normal T1 mapping values for different heart diseases, and how do they compare to healthy hearts? Can we use the simpler "native T1" measurement (without contrast dye) instead of the more complex "ECV" measurement (which requires contrast dye) for diagnosis? Patients with various myocardial conditions will undergo CMR T1 mapping scans. We will analyze the MRI images and clinical records to establish disease-specific reference ranges for T1 mapping parameters, and validate the diagnostic accuracy of T1 mapping
CONDITIONS
Official Title
The Application of T1 Mapping in Real-World
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients 18 years or older with clinically diagnosed myocardial diseases based on current international guidelines
- Diagnosed with one or more of the following: cardiomyopathies (HCM, DCM, RCM, ACM), infiltrative disorders (cardiac amyloidosis, Fabry disease), inflammatory conditions (acute/chronic myocarditis), ischemic heart disease (acute/chronic MI), valvular heart disease (aortic stenosis), arrhythmic conditions (atrial fibrillation), metabolic disorders (iron-overload), neoplastic conditions (cardiac tumors), congenital heart disease, or post-transplant evaluation
- Diagnoses confirmed by guideline-based criteria including echocardiographic parameters, cardiac MRI findings, laboratory biomarkers, or histopathology when indicated
You will not qualify if you...
- Presence of multiple cardiomyopathy diseases or risk factors at the same time
- Contraindications to cardiac MRI examination
- Poor image quality that prevents accurate T1 mapping analysis
- Incomplete clinical data preventing definitive diagnosis confirmation
- Pregnancy or lactation
- Inability to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fuwai Hospital, Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, China, 100000
Actively Recruiting
Research Team
H
Huaying Zhang, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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