Actively Recruiting
Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
Led by Wake Forest University Health Sciences · Updated on 2026-03-18
484
Participants Needed
14
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective randomized clinical trial will compare outcomes between patients treated primarily with a prophylactic antibiotic coated nail and those treated with traditional standard of care intramedullary (IM) nailing.
CONDITIONS
Official Title
Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- Gustilo Type II or III open tibia fracture requiring definitive fixation with intramedullary nail
You will not qualify if you...
- Less than 18 years of age
- Allergy to vancomycin or gentamicin
- Unable to speak English or Spanish
- Pregnant and lactating women
- Prisoner
- Unable to follow up for 12 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 14 locations
1
University of Florida Gainesville
Gainesville, Florida, United States, 32607
Actively Recruiting
2
Florida Orthopaedic Institute
Temple Terrace, Florida, United States, 33637
Actively Recruiting
3
Atrium Health Navicent
Macon, Georgia, United States, 31201
Actively Recruiting
4
University of Kentucky
Lexington, Kentucky, United States, 40536
Actively Recruiting
5
University of North Carolina Chapel Hill
Chapel Hill, North Carolina, United States, 27546
Actively Recruiting
6
Atrium Health Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
Actively Recruiting
7
Atrium Health Cabarrus
Concord, North Carolina, United States, 28025
Actively Recruiting
8
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
9
Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
10
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
11
University of Texas Houston
Houston, Texas, United States, 77030
Actively Recruiting
12
San Antonio Military Medical Center
San Antonio, Texas, United States, 78234
Actively Recruiting
13
Carilion Clinic
Roanoke, Virginia, United States, 24016
Not Yet Recruiting
14
Valley Health System
Winchester, Virginia, United States, 22601
Actively Recruiting
Research Team
R
Rachel Seymour, PhD
CONTACT
C
Christine Churchill, MA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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