Actively Recruiting
Prospective Research Rare Kidney Stones (ProRKS)
Led by Mayo Clinic ยท Updated on 2025-08-06
220
Participants Needed
11
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying rare hereditary and acquired kidney stone diseases including primary hyperoxaluria, cystinuria, Dent disease, adenine phosphoribosyltransferase deficiency (APRTd), Lowe Syndrome, and enteric hyperoxaluria. These conditions cause frequent kidney stones and increase the risk of chronic kidney disease due to crystal buildup. The study aims to understand how inflammation markers in blood and urine relate to disease progression and to compare mechanisms of kidney dysfunction across these disorders. This observational study follows patients with confirmed diagnoses of the listed kidney stone disorders over time. Researchers collect data annually, measuring inflammatory blood and urinary biomarkers and tracking kidney function changes using estimated glomerular filtration rate (eGFR) for up to five years. The study includes several patient groups based on diagnosis, including carriers of Dent disease. Participants will provide blood and urine samples each year to monitor inflammation and kidney function. The study team evaluates disease severity and progression by comparing these markers within and between groups. No experimental treatments are given. Participation involves annual assessments and data collection for up to five years, with ongoing monitoring of kidney health and inflammation markers.
CONDITIONS
Brief Title
Prospective Research Rare Kidney Stones (ProRKS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of primary hyperoxaluria
- Diagnosis of enteric hyperoxaluria
- Diagnosis of Dent Disease
- Diagnosis of Cystinuria
- Diagnosis of adenine phosphoribosyltransferase deficiency (APRTd)
- Diagnosis of Lowe Syndrome
- Diagnosis of Dent Disease Carrier
You will not qualify if you...
- Prior renal failure
- History of liver and/or kidney transplant
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - 5 years
Participants are monitored with annual blood and urine tests to measure inflammatory biomarkers and changes in kidney function over 5 years.
Annual visits for up to 5 years
Trial Site Locations
Total: 11 locations
1
University of Alabama @ Birmingham
Birmingham, Alabama, United States, 35294
Not Yet Recruiting
2
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
Not Yet Recruiting
3
Children's Memorial Hospital
Chicago, Illinois, United States, 60614
Not Yet Recruiting
4
Children's Hospital, Harvard Medical School
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
5
Mayo Clinic Hyperoxaluria Center
Rochester, Minnesota, United States, 55905
Actively Recruiting
6
New York University
New York, New York, United States, 10010
Not Yet Recruiting
7
Cincinnati Children's Hosptial Medical Center
Cincinnati, Ohio, United States, 45229
Not Yet Recruiting
8
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
9
Hosptial of Sick Children
Toronto, Ontario, Canada, M5G 1X8
Not Yet Recruiting
10
Landspitali Universtiy Hospital
Reykjavik, Iceland
Not Yet Recruiting
11
Shaare Zedek Medica Center
Jerusalem, Israel
Not Yet Recruiting
Research Team
B
Barb Seide
J
Julie Olson, RN
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
7
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here