Using Prostaglandin-E Urinary Metabolite PGE-M to Help Diagnose Acute Appendicitis in Children Ages 5 to 17

What this Trial Is About

Diagnosing acute appendicitis in children can be difficult, with delays or mistakes leading to serious problems or unnecessary surgery. Researchers are studying whether prostaglandin E urinary metabolites PGE-M, which rise in other inflammatory conditions, can help diagnose acute appendicitis in children aged 5 to 17 years. This observational study aims to better understand the diagnostic value of PGE-M over a 12-month period. The study involves collecting urine and blood samples from 100 children who come in with acute abdominal pain and signs suggesting appendicitis. Blood tests will measure white blood cell count, neutrophils, and C-reactive protein, while urine tests will check PGE-M and creatinine levels. Participants include children with confirmed appendicitis with or without rupture and a control group where appendicitis is ruled out. During the study, researchers will record clinical data, lab results, diagnostic tests, surgical findings, and final diagnoses. Blood and urine samples will be taken on the day of hospital admission or surgery. The main outcome is measuring urinary PGE-M levels within 72 hours. Because these children already require hospital care or surgery, the study involves minimal risk aside from standard blood sampling discomfort. Participants will be followed throughout their hospital stay as part of the research.

Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children