Actively Recruiting
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Led by KBC Split · Updated on 2025-06-06
100
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Diagnosing acute appendicitis in children can be difficult, with delays or mistakes leading to serious problems or unnecessary surgery. Researchers are studying whether prostaglandin E urinary metabolites (PGE-M), which rise in other inflammatory conditions, can help diagnose acute appendicitis in children aged 5 to 17 years. This observational study aims to better understand the diagnostic value of PGE-M over a 12-month period. The study involves collecting urine and blood samples from 100 children who come in with acute abdominal pain and signs suggesting appendicitis. Blood tests will measure white blood cell count, neutrophils, and C-reactive protein, while urine tests will check PGE-M and creatinine levels. Participants include children with confirmed appendicitis (with or without rupture) and a control group where appendicitis is ruled out. During the study, researchers will record clinical data, lab results, diagnostic tests, surgical findings, and final diagnoses. Blood and urine samples will be taken on the day of hospital admission or surgery. The main outcome is measuring urinary PGE-M levels within 72 hours. Because these children already require hospital care or surgery, the study involves minimal risk aside from standard blood sampling discomfort. Participants will be followed throughout their hospital stay as part of the research.
CONDITIONS
Brief Title
Prostaglandin-E Urinary Metabolite (PGE-M) as a Predictor of Acute Appendicitis in Children
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 5 to 17 years with acute abdominal pain
- Children showing clinical signs of acute appendicitis
You will not qualify if you...
- Previous diagnosis of chronic or malignant disease
- Children who have had previous abdominal surgery
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants provide blood and urine samples on the day of surgery or hospital admission to analyze inflammatory markers and prostaglandin E urinary metabolites.
1 visit (in-person)
Duration - Up to 72 hours
Participants are observed for up to 72 hours after sample collection to track clinical outcomes related to acute appendicitis.
Follow-up monitoring during hospital stay
Trial Site Locations
Total: 1 location
1
University Hospital of Split
Split, Croatia, 21000
Actively Recruiting
Research Team
T
Tomislav Žuvela, Doctor of Medicine, MD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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