Actively Recruiting
Prospective Assessment of the Impact of Psychiatric Status on Clinical Symptom Severity in Patients With Graft-versus-Host Disease (GvHD)
Led by Medical University of Gdansk · Updated on 2026-01-02
200
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand how psychiatric conditions relate to symptom severity and quality of life in patients with graft-versus-host disease (GvHD), a serious complication after stem cell transplantation. The study focuses on assessing mental health status and symptom burden to improve support and care for these patients. It uses standardized tools to measure clinical and psychiatric factors in a systematic way. Patients with chronic GvHD, some diagnosed with depressive or adjustment disorders or cognitive impairment, will be observed to compare symptom severity and psychiatric status. The study does not involve experimental treatments but collects data from patients receiving regular care to evaluate these associations. Follow-up assessments will be conducted over a period of up to 12 months. Participants will provide clinical, psychiatric, and demographic information through validated questionnaires and clinical evaluations. The study will monitor depression levels, symptom burden using the Lee Symptom Scale, and quality of life measures. The research team will assess how psychiatric factors influence GvHD symptoms and explore the effects of different psychiatric treatments on patient outcomes during the study period.
CONDITIONS
Brief Title
Psychiatric Status and Symptom Severity in Graft-versus-Host Disease (GvHD).
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 75 years
- Clinically diagnosed with graft-versus-host disease (GvHD)
- Receiving specialist follow-up care at the Bone Marrow Transplantation Outpatient Clinic, University Clinical Center (UCK), Gdańsk
You will not qualify if you...
- Severe psychiatric disorders that prevent adequate cooperation
- Terminal-stage multiorgan failure
- Refusal to provide informed consent for study participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 12 months
Participants with graft-versus-host disease are observed to assess psychiatric status, symptom severity, and quality of life using standardized instruments.
Baseline and follow-up assessments during the study period
Trial Site Locations
Total: 1 location
1
Department of Hematology and Transplantology
Gdansk, Pomeranian Voivodeship, Poland, 80-214
Actively Recruiting
Research Team
J
Jan Puchowski, M.D.
A
Agnieszka Piekarska, MD PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here