Study of NNC0662-0419 with Birth Control Pills and Stomach Emptying in Women with Overweight or Obesity Who Cannot Become Pregnant, Ages 18 to 64

What this Trial Is About

Researchers are investigating how the drug NNC0662-0419 works together with birth control pills and affects stomach emptying in women who cannot become pregnant and have overweight or obesity. This phase 1 study aims to find out if NNC0662-0419 is safe and how it interacts with other medicines, including a birth control pill called Altavera and a mild painkiller, acetaminophen. The study includes women aged 18 to 64 years who weigh at least 60 kilograms and are generally healthy except for their weight condition. Participants will receive weekly injections of NNC0662-0419 using a pen injector over the treatment period. They will also take the oral contraceptive Altavera under supervision and a single dose of acetaminophen with a standardized meal during the treatment. The study measures how these medicines move through the body, focusing on the levels of the birth control hormones and how the stomach empties after eating. During the study, participants will undergo blood tests to measure the levels of the hormones ethinylestradiol and levonorgestrel and the painkiller acetaminophen at specific times after dosing. Researchers will monitor the participants health through physical exams, vital signs, heart tests, and lab tests. The study will last through the treatment period with assessments before and after dosing to ensure safety and collect data on how the drugs are processed by the body.

A Research Study Looking Into How NNC0662-0419 Works With Birth Control Pills and Emptying of the Stomach in Women Not Able to Become Pregnant With Excess Body Weight