Prevalence and Risk Factors of Anxiety and Depression in Patients with Postherpetic Neuralgia: A Retrospective Study.
Jingyi Du, Guoliang Sun, Han Ma...
https://pubmed.ncbi.nlm.nih.gov/33326962Actively Recruiting
Age: 18Years +
All Genders
ID06449547
Risk Factors Analysis of Anxiety and Depression in Patients With Herpes Zoster Neuralgia and Characteristics of Serum Biomarkers and Functional Brain Magnetic Resonance Changes
Led by Huazhong University of Science and Technology · Updated on 2024-08-26
600
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to explore what factors contribute to anxiety and depression in patients who have herpes zoster neuralgia. It focuses on how certain blood markers and brain activity patterns, seen through functional brain magnetic resonance imaging, change in these patients. The study is observational and seeks to understand these mental health aspects alongside the neuralgia condition. Patients with herpes zoster neuralgia will be evaluated using the Hospital Anxiety and Depression Scale (HADS) questionnaire. Based on their scores, they will be grouped by presence or absence of anxiety or depression. Researchers will collect clinical data, blood samples to measure specific inflammatory and neurotrophic markers, and brain images to analyze changes related to anxiety or depression. During the hospital stay, participants will be assessed with the HADS questionnaire and undergo blood tests measuring various interleukins, interferon, brain-derived neurotrophic factor, and C-reactive protein levels. Functional brain MRI will be performed to study brain activity patterns. The main measurement is the HADS score averaged over about one week. This study involves careful data collection to understand the mental health risk factors in this patient group, with the total observation occurring during the hospital stay.
CONDITIONS
Brief Title
Risk Factors of Anxiety and Depression in Patients With Herpes Zoster Neuralgia
Who Can Participate
Age: 18Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Age more than 18 years old
- Diagnosed as herpes zoster neuralgia
- Signing informed consent
You will not qualify if you...
- Unable to complete the scale assessment
- History of mental illness
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Approximately 1 week during hospital stay
Participants complete the Hospital Anxiety and Depression Scale questionnaire and undergo clinical assessments including serum biomarker tests and functional brain magnetic resonance imaging.
1 hospital stay with assessments conducted during this period
Long-term Monitoring
Duration - Up to study completion in December 2026
Participants' clinical data and biomarker levels are observed and analyzed to explore risk factors of anxiety and depression associated with herpes zoster neuralgia.
Follow-up assessments as scheduled by the study team
Trial Site Locations
Total: 1 location
1
Tongji hospital
Wuhan, Hubei, China, 430031
Actively Recruiting
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Research Team
Y
Yang Shuguang, M.D
M
Mei wei, M.D, PhD
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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