TFOS DEWS II pain and sensation report.
Carlos Belmonte, Jason J Nichols, Stephanie M Cox...
https://pubmed.ncbi.nlm.nih.gov/28736339Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID06841471
Association Between Corneal Sensitivity, Nerve Morphology, Tear Film Homeostasis and Dry Eye Symptoms
Led by Daniela Nosch · Updated on 2025-03-11
140
Participants Needed
1
Research Sites
N/A
Total Duration
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AI-Summary
What this Trial Is About
Researchers are studying how corneal nerve function and structure relate to tear film stability and the health of the eye's surface. They aim to understand if these nerve features differ depending on the severity of dry eye symptoms in adults, including those with and without dry eye disease (DED). The study includes two groups: healthy adults without dry eye and adults diagnosed with dry eye based on the TFOS DEWS II criteria. It is observational and involves measuring corneal nerve function and morphology, comparing these between groups. Participants will undergo assessments within one week to evaluate corneal nerve differences related to dry eye signs and symptoms. The study is led by Daniela Nosch and includes monitoring of tear film and nerve health without treatment interventions. Total participation duration varies by individual.
CONDITIONS
Brief Title
Role of Corneal Nerves in Dry Eye Disease
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Group with DED: Diagnosis of dry eye disease based on the TFOS DEWS II report
- Group without DED: No diagnosis of dry eye disease
- Adults aged 18 years or older
You will not qualify if you...
- Systemic disease that may affect ocular health and innervation
- Injury or history of operations on the front or back parts of the eye affecting corneal structure and physiology
- Regular use of systemic or eye medications known to affect the tear film, except for dry eye medications
- Use of eye drops or makeup on the day of measurement
- Contact lens wearers asked not to wear lenses for 1 week before the first appointment
- Participants using dry eye medications asked to use only preservative-free eye drops on examination days
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
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2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Diagnostic Evaluation
Duration - Within one week
Participants undergo assessments to measure corneal sensitivity, nerve morphology, and tear film homeostasis in relation to dry eye symptoms and signs.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
Institute of Optometrym FHNW
Olten, Switzerland, 4600
Actively Recruiting
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Research Team
D
Daniela S Nosch, BSc MSc PhD
E
Emanuele Käser, BSc MSc
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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