Actively Recruiting
Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes
Led by Weill Cornell Medical College in Qatar · Updated on 2026-04-29
90
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
Sponsors
W
Weill Cornell Medical College in Qatar
Lead Sponsor
H
Hamad Medical Corporation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction. Specifically, the study will evaluate maladaptive angiocrine signaling, calcium signaling pathways, and the role of inflammation in EPC function and the progression of atherosclerosis during T2D development. A sub-study will assess EPC functionality by examining endothelial nitric oxide synthase (eNOS) expression and activity, as well as the effectiveness of in vitro eNOS gene enhancement.
CONDITIONS
Official Title
Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of type 2 diabetes (T2D)
- Male or female
- Age older than 18 years
- Willing to participate and provide written consent
- Agree to provide peripheral blood and urine samples for the study
You will not qualify if you...
- Does not meet inclusion criteria
- Type 1 diabetes, MODY diabetes, or other forms of diabetes
- Active infection, inflammation, cancer, or acute illness (except cardiovascular complications related to diabetes)
- Chronic inflammation such as autoimmune diseases or infections like HIV or chronic hepatitis
- History of malignancy within the past 5 years
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Hamad Medical Corporation
Doha, Qatar
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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