Study of Renal Progenitors and Tubular Cell Response in Children and Teens with Kidney Diseases Using Renal Biopsies

What this Trial Is About

Researchers are studying the role of renal progenitors and polyploid tubular cell responses in kidney diseases affecting children and adolescents up to 17 years old. The focus is on how certain kidney cells, including parietal epithelial cells PECs and tubular progenitors, contribute to kidney damage and regeneration in conditions such as chronic kidney disease CKD and acute kidney injury AKI. This research aims to better understand disease progression by examining kidney biopsy samples using advanced super resolution imaging techniques, linking cellular findings to clinical data and markers of kidney damage. The study involves patients with kidney diseases who are undergoing diagnostic kidney biopsies. The research evaluates renal progenitors in the biopsies to explore their role in disease mechanisms and progression. Clinical data will be collected at the time of biopsy and then at 3, 6, and 12 months, followed by annual follow-ups for up to 9 years. These assessments include DNA and RNA analyses to study tubular cell behavior during AKI and its impact on kidney injury. Participants will have kidney biopsies as part of their clinical care, with additional analyses performed for research purposes. Clinical information will be gathered repeatedly over several years to monitor disease progression and cell activity. The main outcome measured is the role of renal progenitors in glomerular disease progression, with secondary outcomes focused on tubular cell responses during AKI. This long-term follow-up aims to provide insights linking cellular changes in biopsies with patient clinical outcomes.

The Role of Renal Progenitors and Polyploid Tubular Cell Response in Glomerular and Tubular Diseases