Actively Recruiting
Stress as a Key Factor Influencing the Onset and Course of Cardiac Arrest
Led by University Hospital Pilsen · Updated on 2026-05-01
136
Participants Needed
1
Research Sites
13 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to understand long-term stress in patients who have experienced an out-of-hospital cardiac arrest (OHCA) or a heart attack. Stress is known to affect heart health and may influence the onset and progression of cardiac arrest, but specific data linking stress to OHCA is limited. The study focuses on measuring stress hormone levels to better understand how stress relates to cardiac events and patient outcomes. Participants will provide a small 3 cm hair sample to measure cortisol, a hormone that builds up in hair over time and reflects average stress levels over the past three months. The study includes two groups: patients with cardiac arrest and patients with heart attacks. Researchers will compare cortisol levels between these groups and relate them to clinical data, including neurological outcomes and severity of organ damage after resuscitation. During the study, participants' hair cortisol levels will be analyzed and correlated with medical records and care received before and during hospital stays. Neurological function and organ damage will be assessed at 30 and 90 days after cardiac arrest. The study will take place from early 2026 to late 2027, involving regular follow-up assessments to understand how stress impacts recovery and long-term health after these heart-related events.
CONDITIONS
Brief Title
The Role of Stress in Cardiac Arrest (Cortizol CPR)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cardiac arrest
- Heart attack
- Aged between 18 and 100 years
You will not qualify if you...
- Patient's relatives do not agree to the study
- Chronic treatment with corticosteroids or antidepressants
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 3 months
Participants have their hair cortisol levels measured to assess chronic stress exposure over the previous three months. These measurements are correlated with clinical profiles and outcomes.
1 visit (in-person) for hair sampling and follow-up assessments at 30 and 90 days after cardiac arrest
Trial Site Locations
Total: 1 location
1
University Hospital Pilsen
Pilsen, Czech Republic, Czechia, 30100
Actively Recruiting
Research Team
J
Jana Smalcova, MD, Ph.D.
M
Milan Hromadka, MD, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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