Actively Recruiting

Phase Not Applicable
Age: 18Years - 100Years
All Genders
ID07285915

Stress as a Key Factor Influencing the Onset and Course of Cardiac Arrest

Led by University Hospital Pilsen · Updated on 2026-05-01

136

Participants Needed

1

Research Sites

13 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

This research aims to understand long-term stress in patients who have experienced an out-of-hospital cardiac arrest (OHCA) or a heart attack. Stress is known to affect heart health and may influence the onset and progression of cardiac arrest, but specific data linking stress to OHCA is limited. The study focuses on measuring stress hormone levels to better understand how stress relates to cardiac events and patient outcomes. Participants will provide a small 3 cm hair sample to measure cortisol, a hormone that builds up in hair over time and reflects average stress levels over the past three months. The study includes two groups: patients with cardiac arrest and patients with heart attacks. Researchers will compare cortisol levels between these groups and relate them to clinical data, including neurological outcomes and severity of organ damage after resuscitation. During the study, participants' hair cortisol levels will be analyzed and correlated with medical records and care received before and during hospital stays. Neurological function and organ damage will be assessed at 30 and 90 days after cardiac arrest. The study will take place from early 2026 to late 2027, involving regular follow-up assessments to understand how stress impacts recovery and long-term health after these heart-related events.

CONDITIONS

Brief Title

The Role of Stress in Cardiac Arrest (Cortizol CPR)

Who Can Participate

Age: 18Years - 100Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Cardiac arrest
  • Heart attack
  • Aged between 18 and 100 years
Not Eligible

You will not qualify if you...

  • Patient's relatives do not agree to the study
  • Chronic treatment with corticosteroids or antidepressants

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

Surveillance

Duration - Up to 3 months

Participants have their hair cortisol levels measured to assess chronic stress exposure over the previous three months. These measurements are correlated with clinical profiles and outcomes.

1 visit (in-person) for hair sampling and follow-up assessments at 30 and 90 days after cardiac arrest

Trial Site Locations

Total: 1 location

1

University Hospital Pilsen

Pilsen, Czech Republic, Czechia, 30100

Actively Recruiting

Loading map...

Research Team

J

Jana Smalcova, MD, Ph.D.

M

Milan Hromadka, MD, Ph.D.

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NON_RANDOMIZED

Model

PARALLEL

Primary Purpose

SCREENING

Number of Arms

2

Similar Trials

A Randomized Controlled Study of the NEURESCUE Device as an ...

Cardiac Arrest (CA)

Actively Recruiting

2 locations

Assessment of Brain Damage Using Monitoring of Cerebral Oxim...

Cardiac Arrest (CA)

Actively Recruiting

1 location

Cardiac REhabilitation COhort at the Medicine Campus DaVos t...

Cardiac Rehabilitation

Actively Recruiting

1 location

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here