Abnormal laboratory indicators of the subjects need to be excluded, including, but not limited to, the following indicators:

White Blood Cell Count <3*10^9/L Neutrophil Count <1.5*10^9/L <1.5*10^9/L Hemoglobin <85 <85 g/L Platelet Count <80*10^9/L <80*10^9/L Serum Creatinine >1.5*ULN Total Bilirubin >1.5*ULN AST (GOT) >3*ULN ALT (GPT) >3*ULN Alkaline Phosphatase >2*ULN (AST = Aspartate Aminotransferase; GOT = Glutamic-Oxaloacetic Transaminase; ALT = Alanine Aminotransferase; GPT = Glutamic-Pyruvic Transaminase)

Any contraindications to lumbar puncture.

Pregnant or breastfeeding women, and patients with plans to conceive during the trial.

Patients with a known history of allergies to human-derived biological products or those with an allergic predisposition.

Patients who have undergone hematopoietic stem cell transplantation or lymphatic irradiation before enrollment.

Patients who have participated in any other clinical trial within the last 3 months.

Patients with severe comorbidities, including immunodeficiency or coagulation disorders.

Patients with active suicidal ideation within 6 months before screening or have a history of suicide attempts within 3 years before screening.

Patients with severe psychiatric symptoms that prevent clinical cooperation.

Patients with positive for alcohol addiction or drug abuse.

Patients with malignant tumors.

Patients who have experienced any of the following events within 12 weeks before enrollment: myocardial infarction, unstable ischemic heart disease, stroke, or New York Heart Association Class IV heart failure.

Patients with persistent systemic infections and severe local infections.

Patients unable to undergo magnetic resonance imaging during the trial.

Patients deemed unsuitable for participation by the investigator.