Study of Visual Pathway Injury, Blood Markers, and MRI Changes in Multiple Sclerosis and Related Disorders

What this Trial Is About

Researchers are investigating risk factors for disability progression in people with Multiple Sclerosis and related disorders MSRD including conditions like clinically isolated syndrome, neuromyelitis optica spectrum disorders, and myelin oligodendrocyte glycoprotein antibody disorders. The study aims to see if combining visual assessments, blood markers, and detailed MRI scans of the brain, eyes, and spinal cord can predict changes in disability related to these neurological diseases. This observational study also includes healthy volunteers for comparison. Participants will first be screened through review of their medical and MRI records, including scans done at Cedars-Sinai or elsewhere. Those eligible will join the main study where demographic data, medical history, and disability assessments will be collected. Historic MRI data obtained during routine care will also be used. There is an optional sub-study where participants may opt for research blood draws, genetic or stem cell sampling, visual testing, and research MRI scans. Participants can choose whether to join the sub-study and still remain in the main study. Participants may stay in the study as long as they wish, remain eligible, and the study is open. During involvement, researchers will review medical records, collect assessments, and track disability progression over time. Safety considerations include MRI eligibility and ocular health. Compensation for parking is provided if participants undergo optional sub-study procedures. The primary outcome is identifying risk factors for disability progression over 10 years, along with exploring effects of therapies and biomarkers influencing disease outcomes.

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