Paramagnetic Rim Lesions Are Associated With Trans-Synaptic Degeneration of the Visual Pathway in Multiple Sclerosis.
Abdul Jaber Tayem, Angel Liu, Sargis Manukyan...
https://pubmed.ncbi.nlm.nih.gov/41841206Actively Recruiting
Age: 18Years +
All Genders
Healthy Volunteers
ID05204459
Investigating Visual Pathway Injury, Radiological and Blood Biomarkers in Multiple Sclerosis and Related Disorders
Led by Cedars-Sinai Medical Center · Updated on 2024-02-06
1000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating risk factors for disability progression in people with Multiple Sclerosis and related disorders (MSRD) including conditions like clinically isolated syndrome, neuromyelitis optica spectrum disorders, and myelin oligodendrocyte glycoprotein antibody disorders. The study aims to see if combining visual assessments, blood markers, and detailed MRI scans of the brain, eyes, and spinal cord can predict changes in disability related to these neurological diseases. This observational study also includes healthy volunteers for comparison. Participants will first be screened through review of their medical and MRI records, including scans done at Cedars-Sinai or elsewhere. Those eligible will join the main study where demographic data, medical history, and disability assessments will be collected. Historic MRI data obtained during routine care will also be used. There is an optional sub-study where participants may opt for research blood draws, genetic or stem cell sampling, visual testing, and research MRI scans. Participants can choose whether to join the sub-study and still remain in the main study. Participants may stay in the study as long as they wish, remain eligible, and the study is open. During involvement, researchers will review medical records, collect assessments, and track disability progression over time. Safety considerations include MRI eligibility and ocular health. Compensation for parking is provided if participants undergo optional sub-study procedures. The primary outcome is identifying risk factors for disability progression over 10 years, along with exploring effects of therapies and biomarkers influencing disease outcomes.
CONDITIONS
Brief Title
MS-ResearchBiomarkerS
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Diagnosis of MS, CIS, or RIS based on the 2017 revised McDonald criteria
- Diagnosis of NMOSD based on the 2015 revised consensus diagnostic criteria
- Diagnosis of MOG-related encephalomyelitis, optic neuritis, or associated disease
- Diagnosis of neurological disorders other than MSRD
- Healthy volunteer
- Age 18 years or older
- Able to give informed consent
You will not qualify if you...
- Contraindications to MRI such as metallic implants, foreign bodies, claustrophobia, MRI-incompatible pacemakers or prosthetic heart valves
- Pregnancy for MRI portions of the study
- Recent ocular surgery within the past two months
- Refractive errors greater than or equal to ±6 diopters
- Eye diseases that affect or confound visual testing (e.g., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) for review of medical and MRI records
Monitoring
Duration - Ongoing with no prespecified end date while participants remain eligible and willing
Participants provide demographic data, medical history, and undergo disability assessments. Historic MRI data obtained as part of standard care is collected. Participants may optionally undergo additional research procedures such as blood draws, visual assessments, and research MRI scans.
Visits as needed depending on optional sub-study participation
Trial Site Locations
Total: 1 location
1
Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
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Research Team
O
Omar Al-Louzi, MD
G
Group Neurology Research
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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