Actively Recruiting
Serial Assessment of Fertility Experiences
Led by Children's Hospital Medical Center, Cincinnati · Updated on 2026-02-04
250
Participants Needed
3
Research Sites
651 weeks
Total Duration
On this page
Sponsors
C
Children's Hospital Medical Center, Cincinnati
Lead Sponsor
T
The University of The West Indies
Collaborating Sponsor
AI-Summary
What this Trial Is About
The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children. A second goal is to see how hydroxyurea affects pregnancy outcomes, by comparing people who take the medicine to those who don't.
CONDITIONS
Official Title
Serial Assessment of Fertility Experiences
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with documented sickle cell anemia (SCA).
- At least 8 years of age at the time of enrollment.
- Enrolled on the EXTEND or SACRED study.
- Provide informed consent.
- Able to take part in all parts of the study, including treatments, check-ups, and follow-up visits.
You will not qualify if you...
- Currently taking part in another treatment study (not EXTEND or SACRED).
- Has received other treatments for sickle cell disease in the past 6 months.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
Centro de Obstetricia y Ginecologia
Santo Domingo, Dominican Republic
Actively Recruiting
2
Caribbean Institute for Health Research, University of West Indies
Kingston, Jamaica
Actively Recruiting
3
Buganda Medical Centre
Mwanza, Tanzania
Actively Recruiting
Research Team
T
Teresa Latham, DrPh
CONTACT
R
Russell E Ware, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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