Actively Recruiting
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Led by University of Missouri-Columbia · Updated on 2025-05-29
72
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating the differences between men and women in how their blood vessels respond to low oxygen levels, especially considering the role of obesity. This study focuses on understanding the mechanisms behind sex differences in hypoxic vasodilation and how obesity might impact this process. The goal is to improve current treatments and support the development of new therapies for conditions linked to low oxygen and cardiovascular risk. Participants, including both men and women, will undergo controlled exposure to low oxygen while wearing a mask to maintain stable carbon dioxide levels. During this time, various drugs such as Propranolol Hydrochloride, Isoproterenol, Phentolamine Mesylate, and Norepinephrine will be infused regionally into the forearm to study vascular responses. The study includes measuring changes in forearm blood flow conductance with these drug infusions during normal oxygen and low oxygen conditions. Throughout the study, participants will have their vascular responses assessed via intra-arterial drug infusions and pulse oximetry to monitor oxygen levels. The main outcome measured is the change in forearm vascular conductance from baseline to the last minute of drug infusion. The study welcomes healthy volunteers aged 18 to 45 years, with assessments including monitoring blood pressure and other health measures to ensure safety. Participation may last until the study's completion in June 2026.
CONDITIONS
Brief Title
Sex Disparities in Hypoxic Vasodilation and Impact of Obesity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI >18 kg/m2
- Age between 18 and 45 years
- Willingness to participate as a healthy volunteer
You will not qualify if you...
- Pregnancy or breastfeeding
- Diagnosed sleep apnea or apnea-hypopnea index greater than 10 events per hour
- Current smoking or nicotine use
- Increased risk of bleeding or clotting disorders, or use of anticoagulation therapy
- Presence of nerve or neurologic disease
- Cardiovascular, liver, kidney, or respiratory disease
- Blood pressure equal to or higher than 140/90 mmHg
- Diabetes or polycystic ovarian syndrome
- Communication barriers
- Use of prescription medications or sensitivity to lidocaine
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants receive regional forearm drug infusions during controlled exposures to low oxygen levels to assess cardiovascular responses.
1 in-person visit with multiple drug infusion assessments
Trial Site Locations
Total: 1 location
1
University of Missouri
Columbia, Missouri, United States, 65211
Actively Recruiting
Research Team
J
Jacqueline K Limberg, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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