Comparison of Shear-wave Elastography to Respiratory Function Testing to Measure Diaphragm Muscle Forces

What this Trial Is About

Researchers are studying the relationship between transdiaphragmatic pressure and diaphragm shear-wave elastography during advanced respiratory muscle testing. The study focuses on measuring diaphragm muscle forces using volitional efforts like maximal inspiratory and expiratory pressures, the Valsalva maneuver, and maximal phrenic nerve stimulation. The goal is to better understand how these measurements compare and relate to each other in healthy adults. Participants will undergo standard respiratory function tests combined with ultrasound-based shear-wave elastography of the diaphragm muscle. All subjects receive these tests during various respiratory behaviors and conditions to assess diaphragm muscle activity. The shear-wave elastography is a diagnostic imaging technique that uses ultrasound to evaluate diaphragm function. During the study, researchers will measure shear wave speed over approximately 3 hours to evaluate diaphragm muscle forces. Participants will undergo multiple respiratory tests and ultrasound imaging sessions. The study is open to adult healthy volunteers, and safety and respiratory function will be monitored throughout. The total study duration and follow-up details depend on the individual participant's testing schedule.

Shear-wave Elastography Compared to Respiratory Function Testing