Actively Recruiting
STI Prophylaxis and Emergence of Antimicrobial Resistance
Led by University College, London · Updated on 2025-03-27
108
Participants Needed
1
Research Sites
115 weeks
Total Duration
On this page
Sponsors
U
University College, London
Lead Sponsor
U
University of Oxford
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this observational study is to understand the risk of antibiotic resistance and changes in the human microbiome (bacteria that live inside and on us), if people use antibiotics to prevent sexually transmitted infections (STI prophylaxis, doxycycline post-exposure prophylaxis, or 'doxyPEP'). The study will assess how easy and acceptable it is to find antibiotic resistance and microbiome changes in the throats and guts of men-who-have-sex-with-men (MSM) who use STI prophylaxis. The study will recruit 108 MSM who are using and not using STI prophylaxis. Participants will visit the clinic every 6 months. At each visit, they will provide a throat swab and stool sample, and complete a questionnaire. DNA of the bacteria from the samples will be analysed to identify the bacteria and look for antibiotic resistance.
CONDITIONS
Official Title
STI Prophylaxis and Emergence of Antimicrobial Resistance
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 63; 18 years
- Identifies as a man (cis or trans)
- Has sex with men
- Able to provide informed consent
You will not qualify if you...
- Use of an antibiotic other than doxycycline in the 3 months prior to enrolment
- Currently being treated for an STI with doxycycline
- Use of doxycycline within the prior 3 months for an indication other than STI treatment or STI prevention
AI-Screening
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Trial Site Locations
Total: 1 location
1
Central and North West London NHS Foundation Trust
London, United Kingdom
Actively Recruiting
Research Team
M
Manik Kohli, MBChB MSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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