Strength-Endurance Circuit Training in Parkinson's Disease: Effects on Disease Severity, Physical Performance, Blood Biomarkers and Quality of Life.

What this Trial Is About

Researchers are evaluating whether adding strength training to aerobic training can provide similar or greater benefits for people with Parkinson's disease compared to aerobic training alone. The trial focuses on how these exercise programs affect physical performance, disease severity, blood biomarkers, and quality of life in patients with idiopathic Parkinson's disease. This study is sponsored by the General University Hospital, Prague and involves a 12-week intervention followed by a 3-month follow-up. Participants are assigned to one of three groups: combined strength-endurance circuit training, endurance circuit training alone, or a control group with no intervention. Both exercise groups attend two 1-hour training sessions each week for 12 weeks, completing a total of 24 sessions. The combined training includes warm-up, strength and endurance exercises, and cool-down, while the endurance group performs endurance exercises only. During the study, participants will undergo assessments before and after the 12-week training and again after a 3-month follow-up. These include measuring Parkinson's disease severity using the Movement Disorders Society Unified Parkinson's Disease Rating Scale, physical performance tests, blood biomarker analysis, and quality of life questionnaires. Selected patients will also use a smartwatch to track their average daily steps before, during, and after the intervention. Attendance and adherence to training sessions are monitored throughout the study.

Strength-Endurance Circuit Training in Parkinson's Disease