Study of Brain and Spinal Cord Nerve Connections in Children with Muscle Spasticity Using Monitoring During Selective Rhizotomy Surgery

What this Trial Is About

Researchers are investigating how the brain and spinal cord interact during selective dorsal rhizotomy surgery to treat muscle spasticity in children and adolescents. This study aims to better understand the nerve mechanisms involved by using advanced recordings of electrical activity in the nervous system, which have not been done before. Insights gained may help improve the surgical procedure for spasticity treatment. The study involves recording electrical signals from the brain, spinal cord, nerve roots, and muscles during the surgery using specialized neuroelectrophysiological monitoring equipment. This includes scalp electrodes, spinal cord electrodes, root electrodes, and muscle needle electrodes placed while the patient is under general anesthesia. The procedure captures nerve activity at multiple levels throughout the operation. Participants aged 3 to 17 years scheduled for this surgery will be involved. Researchers will measure changes in nerve signal synchronization before and after surgery as the primary outcome. The process includes continuous monitoring during the operation, and all data collection occurs in the operating room under anesthesia. The total study participation is tied to the surgical procedure timeline.

Study of Brain-spinal Cord Neural Connectivity in Spasticity