Actively Recruiting
Study of the Contribution of Mutant p53/YAP Proteins to Therapy Resistance in Recurrent Head and Neck Cancer
Led by Regina Elena Cancer Institute · Updated on 2025-01-24
18
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Multicenter, non-interventional, retrospective/prospective study of a biological nature, on patients affected by head and neck tumors, for which the collection and use of tissue samples is planned for the study of the mutational profile, the transcriptional profile and the proteomic profile.
CONDITIONS
Official Title
Study of the Contribution of Mutant p53/YAP Proteins to Therapy Resistance in Recurrent Head and Neck Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age over 18
- Patients with squamous cell tumors of the oral cavity, pharynx or larynx
- Surgical patients with primary HNSCC tumors, who have not had previous tumors in other sites or adjuvant treatments prior to surgery
- Availability of adequate material (tissue) for the planned analyses
- Availability of follow-up data for at least one year (retrospective part)
- Written informed consent (prospective part and/or, for the retrospective part, traceable patients and/or patients in follow-up and/or if necessary for the legal nature/institutional purposes of the participating centers)
You will not qualify if you...
- Presence of distant metastases at the time of diagnosis
- Previous head and neck cancer
- Second cancer undergoing treatment or follow-up for less than 5 years
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS National Cancer institute
Roma, Rome, Italy, 00144
Actively Recruiting
Research Team
G
Giovanni Blandino, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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