Actively Recruiting
A Phase 3 Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Obesity or Overweight, Without Type 2 Diabetes
Led by Eli Lilly and Company · Updated on 2026-06-04
1980
Participants Needed
169
Research Sites
121 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the effects of eloralintide in adults who are obese or overweight but do not have type 2 diabetes. The study aims to evaluate how well and how safely eloralintide works in this group. This phase 3 trial is sponsored by Eli Lilly and Company and includes adults with specific weight-related health conditions or a history of unsuccessful weight loss efforts. Participants in this randomized, double-blind study will receive weekly subcutaneous injections of eloralintide at one of four doses or a placebo. The main phase lasts about 75 weeks, during which participants are monitored closely. Those with prediabetes at the start may continue in an extension phase for an additional two years to further assess long-term effects. Throughout the study, participants will undergo various assessments including body weight, body fat mass, waist circumference, blood pressure, blood markers like triglycerides and HbA1c, and quality of life questionnaires. Researchers will track changes from baseline at week 64 and monitor the onset of type 2 diabetes up to week 191. Safety and medication use will also be observed, ensuring comprehensive evaluation over the course of participation.
CONDITIONS
Brief Title
A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Body mass index (BMI) of 30 kg/m2 or higher, or BMI of 27 kg/m2 with at least one weight-related health condition such as high blood pressure, dyslipidemia, obstructive sleep apnea, or heart disease
- Stable body weight with less than 5% change in the 90 days before screening
- History of at least one unsuccessful attempt to lose weight through diet
You will not qualify if you...
- Prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if done more than 1 year before screening)
- Prior or planned endoscopic or device-based therapy for obesity (device removal must have been more than 6 months before screening)
- Diagnosis of type 1 or type 2 diabetes
- Heart attack, stroke, coronary artery revascularization, unstable angina, or hospitalization for congestive heart failure within 90 days before screening
- History or diagnosis of severe congestive heart failure (New York Heart Association Class IV)
- Use of medications or alternative remedies intended for weight loss within 90 days before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 64 weeks
Participants receive once weekly subcutaneous injections of eloralintide or placebo as part of the study treatment.
Weekly visits for up to 64 weeks
Trial Site Locations
Total: 169 locations
1
MFA Clinical Research
Tuscaloosa, Alabama, United States, 35405
Actively Recruiting
2
Headlands Research - Scottsdale
Scottsdale, Arizona, United States, 85260
Actively Recruiting
3
Neighborhood Healthcare Institute of Health
Escondido, California, United States, 92025
Actively Recruiting
4
Ark Clinical Research - Fountain Valley
Fountain Valley, California, United States, 92708
Actively Recruiting
5
Desert Oasis Healthcare Medical Group
Palm Springs, California, United States, 92262
Actively Recruiting
6
Peninsula Research Associates
Rolling Hills Estates, California, United States, 90274
Actively Recruiting
7
Care Access - Sacramento
Sacramento, California, United States, 95831
Actively Recruiting
8
Southern California Clinical Research
Santa Ana, California, United States, 92701
Actively Recruiting
9
University Clinical Investigators, Inc.
Tustin, California, United States, 92780
Actively Recruiting
10
Chase Medical Research, LLC
Waterbury, Connecticut, United States, 06708
Actively Recruiting
11
JEM Research Institute
Atlantis, Florida, United States, 33462
Actively Recruiting
12
BioMed Research & Medical Center
Miami, Florida, United States, 33156
Actively Recruiting
13
Adult Medicine of Lake County, Inc.
Mt. Dora, Florida, United States, 32757
Actively Recruiting
14
American Research Centers of Florida
Pembroke Pines, Florida, United States, 33027
Actively Recruiting
15
AHF Pensacola
Pensacola, Florida, United States, 32503
Actively Recruiting
16
IMA Clinical Research St. Petersburg
St. Petersburg, Florida, United States, 33704
Actively Recruiting
17
Teak Research Consults - Dunwoody
Dunwoody, Georgia, United States, 30338
Actively Recruiting
18
Teak Research Consults
Lawrenceville, Georgia, United States, 30043
Actively Recruiting
19
Clinical Research Atlanta
Stockbridge, Georgia, United States, 30281
Actively Recruiting
20
East-West Medical Research Institute
Honolulu, Hawaii, United States, 96814
Actively Recruiting
21
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa, United States, 50266
Actively Recruiting
22
Cotton O'Neil Clinical Research Center
Topeka, Kansas, United States, 66606
Actively Recruiting
23
Care Access - Lake Charles (Bayou Pines)
Lake Charles, Louisiana, United States, 70601
Actively Recruiting
24
MedStar Good Samaritan Hospital
Baltimore, Maryland, United States, 21239
Actively Recruiting
25
MedStar Health Research Institute (MedStar Physician Based Research Network)
Hyattsville, Maryland, United States, 20782
Actively Recruiting
26
Care Access - Quincy
Quincy, Massachusetts, United States, 02169
Actively Recruiting
27
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States, 48098
Actively Recruiting
28
AMR Clinical
Las Vegas, Nevada, United States, 89119
Actively Recruiting
29
IMA Clinical Research Warren
Warren Township, New Jersey, United States, 07059
Actively Recruiting
30
Albuquerque Clinical Trials, Inc.
Albuquerque, New Mexico, United States, 87102
Actively Recruiting
31
Rochester Clinical Research, LLC
Rochester, New York, United States, 14609
Actively Recruiting
32
Monroe Biomedical Research
Monroe, North Carolina, United States, 28112
Actively Recruiting
33
Preferred Primary Care Physicians
Uniontown, Pennsylvania, United States, 15401
Actively Recruiting
34
Tribe Clinical Research, LLC
Greenville, South Carolina, United States, 29607
Actively Recruiting
35
Accellacare - Mt Pleasant
Mt. Pleasant, South Carolina, United States, 29464
Actively Recruiting
36
AMR Clinical
Nashville, Tennessee, United States, 37203
Actively Recruiting
37
The University of Texas Health Science Center at Houston
Bellaire, Texas, United States, 77401
Actively Recruiting
38
Velocity Clinical Research, Dallas
Dallas, Texas, United States, 75230
Actively Recruiting
39
UT Southwestern Medical Center
Dallas, Texas, United States, 75390-9302
Actively Recruiting
40
IMA Clinical Research San Antonio
San Antonio, Texas, United States, 78229
Actively Recruiting
41
AMR Clinical
Norfolk, Virginia, United States, 23502
Actively Recruiting
42
CONEXA Investigacion Clinica S.A.
Buenos Aires, Argentina, 1012
Not Yet Recruiting
43
CIPREC
Buenos Aires, Argentina, 1061
Not Yet Recruiting
44
Cicemo Srl
Buenos Aires, Argentina, 1424
Not Yet Recruiting
45
Cardiología Palermo
Buenos Aires, Argentina, 1425
Not Yet Recruiting
46
Glenny Corp. S.A.
Buenos Aires, Argentina, 1430
Not Yet Recruiting
47
CARDIAMET Investigaciones Médicas
Buenos Aires, Argentina, C1014ACP
Not Yet Recruiting
48
Centro Médico Viamonte
Buenos Aires, Argentina, C1120AAC
Not Yet Recruiting
49
Fundación Respirar
Buenos Aires, Argentina, C1426ABP
Not Yet Recruiting
50
Instituto de Investigaciones Clínicas Córdoba
Córdoba, Argentina, 5000
Not Yet Recruiting
51
CIPADI - Centro Integral de Prevencion y Atencion en Diabetes
Godoy Cruz, Argentina, M5501ARP
Not Yet Recruiting
52
INECO Neurociencias Oroño
Rosario, Argentina, 2000
Not Yet Recruiting
53
Instituto Especialidades de la Salud Rosario
Rosario, Argentina, 2000
Not Yet Recruiting
54
Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica
Rosario, Argentina, 2000
Not Yet Recruiting
55
Laboratorio de Hemostasia y Trombosis
Rosario, Argentina, S2000DTB
Not Yet Recruiting
56
Centro de Investigaciones Médicas Tucuman
SAN M. de Tucuman, Argentina, T4000AXL
Not Yet Recruiting
57
Centro Modelo de Cardiología
San Miguel de Tucumán, Argentina, 4000
Not Yet Recruiting
58
Centro de Salud e Investigaciones Médicas
Santa Rosa, Argentina, L6300
Not Yet Recruiting
59
Emeritus Research
Botany, Australia, 2019
Not Yet Recruiting
60
Core Research Group
Brisbane, Australia, 4064
Not Yet Recruiting
61
Emeritus Research
Camberwell, Australia, 3124
Not Yet Recruiting
62
Life Clinical Research
Ipswich, Australia, 4305
Not Yet Recruiting
63
Paratus Clinical Research Central Coast
Kanwal, Australia, 2259
Not Yet Recruiting
64
University of the Sunshine Coast (UniSC) Clinical Trials - Meadowbrook
Meadowbrook, Australia, 4131
Not Yet Recruiting
65
Momentum Sunshine
Melbourne, Australia, 3021
Not Yet Recruiting
66
Paratus Clinical Research - Melbourne
Melbourne, Australia, 3070
Not Yet Recruiting
67
AIM Research
Merewether, Australia, 2291
Not Yet Recruiting
68
Fusion Clinical Research
Norwood, Australia, 5067
Not Yet Recruiting
69
USC Clinical Trials Sunshine Coast
Sippy Downs, Australia, 4556
Not Yet Recruiting
70
ANIMA Research
Diepenbeek, Belgium, 3590
Actively Recruiting
71
Jessa Ziekenhuis
Hasselt, Belgium, 3500
Actively Recruiting
72
Kormont
Kluisbergen, Belgium, 9690
Actively Recruiting
73
Gezondheidshuis De Gloed
Machelen, Belgium, 9870
Actively Recruiting
74
Chronos Pesquisa Clínica
Brasília, Brazil, 72145-450
Not Yet Recruiting
75
Instituto de Pesquisa clinica de Campinas
Campinas, Brazil, 13060-080
Not Yet Recruiting
76
Private Practice - Dr.Miguel N. Hissa
Fortaleza, Brazil, 60430-350
Not Yet Recruiting
77
Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, Brazil, 17504-072
Not Yet Recruiting
78
Núcleo de Pesquisa Clínica do Rio Grande do Sul
Porto Alegre, Brazil, 90430-001
Not Yet Recruiting
79
IBPClin - Instituto Brasil de Pesquisa Clínica
Rio de Janeiro, Brazil, 20241-180
Not Yet Recruiting
80
Ruschel Medicina e Pesquisa Clínica
Rio de Janeiro, Brazil, 22270-060
Not Yet Recruiting
81
CPCLIN
São Paulo, Brazil, 01228-200
Not Yet Recruiting
82
CEPIC - Centro Paulista de Investigação Clínica
São Paulo, Brazil, 04266-010
Not Yet Recruiting
83
CEDOES
Vitória, Brazil, 29055450
Not Yet Recruiting
84
Integral Pesquisa e Ensino
Votuporanga, Brazil, 15500-269
Not Yet Recruiting
85
Aggarwal and Associates Limited
Brampton, Canada, L6T 0G1
Actively Recruiting
86
Med Trust Research
Courtice, Canada, L1E 2J5
Actively Recruiting
87
Dawson Clinical Research Inc.
Guelph, Canada, N1H 1B1
Actively Recruiting
88
Winterberry Research Inc.
Hamilton, Canada, L8J 0B6
Actively Recruiting
89
The Wharton Medical Clinic Clinical Trials Inc
Hamilton, Canada, L8L 5G8
Actively Recruiting
90
Alpha Recherche Clinique
Québec, Canada, G2J 0C4
Actively Recruiting
91
ALPHA Recherche Clinique
Québec, Canada, G3K 2P8
Actively Recruiting
92
Bluewater Clinical Research Group Inc.
Sarnia, Canada, N7T 4X3
Actively Recruiting
93
Diex Recherche Inc. Division Trois-Rivieres
Trois-Rivières, Canada, G9A 4P3
Actively Recruiting
94
Luhe Hospital
Beijing, China, 1001199
Not Yet Recruiting
95
Beijing Pinggu District Hospital
Beijing, China, 101200
Not Yet Recruiting
96
Sichuan Provincial People's Hospital
Chengdu, China, 610072
Not Yet Recruiting
97
West China Hospital Sichuan University
Chengdu, China, 610041
Not Yet Recruiting
98
Zhujiang Hospital
Guangzhou, China, 510280
Not Yet Recruiting
99
The Second People's Hospital of Hefei
Hefei, China, 230011
Not Yet Recruiting
100
Jinan Central Hospital
Jinan, China, 250013
Not Yet Recruiting
101
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang Shi, China, 471003
Not Yet Recruiting
102
Jiangxi Provincial People's Hospital
Nanchang, China, 330006
Not Yet Recruiting
103
Nanjing First Hospital
Nanjing, China, 210006
Not Yet Recruiting
104
Jiangsu Province Official Hospital
Nanjing, China, 210008
Not Yet Recruiting
105
Zhongda Hospital Southeast University
Nanjing, China, 210009
Not Yet Recruiting
106
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, China, 210011
Not Yet Recruiting
107
Shanghai Sixth People's Hospital
Shanghai, China
Not Yet Recruiting
108
Zentrum fur klinische Forschung - Köln
Cologne, Germany, 51069
Actively Recruiting
109
Universitaetsklinikum Carl Gustav Carus Dresden
Dresden, Germany, 01307
Actively Recruiting
110
StudyPoint Duisburg
Duisburg, Germany, 47269
Actively Recruiting
111
InnoDiab Forschung Gmbh
Essen, Germany, 45136
Actively Recruiting
112
Medizentrum Essen Borbeck
Essen, Germany, 45355
Actively Recruiting
113
Diabetes Zentrum Wilhelmsburg
Hamburg, Germany, 21109
Actively Recruiting
114
Diabeteszentrum Hamburg West
Hamburg, Germany, 22607
Actively Recruiting
115
AmBeNet GmbH
Leipzig, Germany, 04107
Actively Recruiting
116
Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz
Lingen, Germany, 49808
Actively Recruiting
117
BAG Drs. Med. Quist PartG
Mainz, Germany, 55128
Actively Recruiting
118
CRS Clinical Research Services Mannheim
Mannheim, Germany, 68167
Actively Recruiting
119
RED-Institut GmbH
Oldenburg, Germany, 23758
Actively Recruiting
120
Praxis Sauter & Sauter & Vorbach
Wangen, Germany, 88239
Actively Recruiting
121
Endolife Speciality Hospitals
Guntur, India, 522001
Not Yet Recruiting
122
Gauhati Medical College and Hospital
Guwahati, India, 781032
Not Yet Recruiting
123
Care Hospitals Hyderabad- Banjara Hills
Hyderabad, India, 500034
Not Yet Recruiting
124
Mandya Institute Of Medical Sciences
Mandya, India, 571401
Not Yet Recruiting
125
Topiwala National Medical College & B. Y. L. Nair Charitable Hospital
Mumbai, India, 400008
Not Yet Recruiting
126
Mysore Medical College
Mysore, India, 570001
Not Yet Recruiting
127
All India Institute of Medical Sciences (AIIMS) - Nagpur
Nagpur, India, 441108
Not Yet Recruiting
128
Supe Heart & Diabetes Hospital and Research Centre
Nashik, India, 422002
Not Yet Recruiting
129
Lifepoint Multispeciality Hospital
Pune, India, 411057
Not Yet Recruiting
130
Prabhu Diabetes Multi-Speciality Centre
Trichy, India, 620001
Not Yet Recruiting
131
Adachi Kyosai Hospital
Adachi-ku, Japan, 120-0022
Actively Recruiting
132
Nihonbashi Sakura Clinic
Chūōku, Japan, 103-0025
Actively Recruiting
133
Medical Corporation Chiseikai Tokyo Center Clinic
Chūōku, Japan, 103-0027
Actively Recruiting
134
Tokyo-Eki Center-building Clinic
Chūōku, Japan, 103-0027
Actively Recruiting
135
Boocs Clinic Fukuoka
Fukuoka, Japan, 812-0025
Actively Recruiting
136
Patient First Clinic Ginza-Shimbashi
Minato, Japan, 105-0004
Actively Recruiting
137
Kanno Naika
Mitaka, Japan, 181-0013
Actively Recruiting
138
Medical Corporation Heishinkai OCROM Clinic
Suita-shi, Japan, 565-0853
Actively Recruiting
139
Higashi Shinjuku Clinic
Tokyo, Japan, 169-0072
Actively Recruiting
140
Zdrowie Osteo-Medic
Bialystok, Poland, 15-351
Actively Recruiting
141
Legeartis - Poradnie Specjalistyczne
Bialystok, Poland, 15-404
Actively Recruiting
142
Medyczne Centrum Diabetologiczno Endokrynologiczno Metaboliczne DIAB-ENDO-MET
Krakow, Poland, 31-261
Actively Recruiting
143
Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna
Lodz, Poland, 90-338
Actively Recruiting
144
Gabinety TERPA
Lublin, Poland, 20-333
Actively Recruiting
145
Ekamed
Lublin, Poland, 20-718
Actively Recruiting
146
Centrum Zdrowia Metabolicznego Pawel Bogdanski
Poznan, Poland, 60-589
Actively Recruiting
147
Pracownia Badań Klinicznych Salus
Wroclaw, Poland, 53-034
Actively Recruiting
148
Samodzielny Publiczny Szpital Kliniczny nr 1 SUM
Zabrze, Poland, 41-800
Not Yet Recruiting
149
Puerto Rico Health and Wellness Institute
Dorado, Puerto Rico, 00646
Actively Recruiting
150
Wellness clinical Research Vega Baja
Vega Baja, Puerto Rico, 00693
Actively Recruiting
151
Gachon University Gil Medical Center
Namdong-gu, South Korea, 21565
Actively Recruiting
152
Konyang University Hospital
Seogu, South Korea, 35365
Not Yet Recruiting
153
Seoul National University Bundang Hospital
Seongnam, South Korea, 13620
Not Yet Recruiting
154
Seoul National University Hospital
Seoul, South Korea, 03080
Actively Recruiting
155
Pusan National University Yangsan Hospital
Yangsan, South Korea, 50612
Not Yet Recruiting
156
Chiayi Christian Hospital
Chiayi City, Taiwan, 600
Not Yet Recruiting
157
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807
Not Yet Recruiting
158
Chang Gung Memorial Hospital at Kaohsiung
Kaohsiung Niao Sung Dist, Taiwan, 83301
Not Yet Recruiting
159
National Taiwan University Hospital
Taipei, Taiwan, 10002
Not Yet Recruiting
160
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Not Yet Recruiting
161
Layton Medical Centre
Blackpool, United Kingdom, FY3 7EN
Not Yet Recruiting
162
Bradford on Avon Health Centre
Bradford-on-Avon, United Kingdom, BA15 1DQ
Not Yet Recruiting
163
Ashton Medical Group - Chapel House
Lancashire, United Kingdom, OL6 6EW
Not Yet Recruiting
164
Royal Lancaster Infirmary
Lancaster, United Kingdom, LA1 4RP
Not Yet Recruiting
165
Altnagelvin Area Hospital
Londonderry, United Kingdom, BT47 6SB
Not Yet Recruiting
166
Bodyline Clinic - Openshaw
Manchester, United Kingdom, M11 1AA
Not Yet Recruiting
167
Wansford Research Limited
Peterborough, United Kingdom, PE8 6PL
Not Yet Recruiting
168
Abbeywell Surgery
Romsey, United Kingdom, SO51 7QN
Not Yet Recruiting
169
Rame Group Practice
Torpoint, United Kingdom, PL11 2TB
Not Yet Recruiting
Research Team
T
Trial question or participation questions: 1-877-CTLILLY (1-877-285-4559) or
P
Physicians interested in becoming principal investigators please contact
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
5
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