Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung

What this Trial Is About

Researchers are investigating the immune patterns in the respiratory system to better understand the immune-related causes of common lung diseases like asthma and chronic obstructive pulmonary disease (COPD). This study includes people diagnosed or suspected to have airway disease, as well as healthy volunteers, to compare inflammatory and physiological profiles. The study is observational and focuses on identifying immune signatures throughout the lungs and circulation that relate to these airway conditions. Participants will be invited to join at key clinical moments such as treatment changes or disease flare-ups and may attend optional bronchoscopy visits to collect lung samples. The study involves yearly visits, with additional visits during disease exacerbations or treatment adjustments. Procedures include questionnaires, lung function tests (spirometry or oscillometry), sputum and nasal sample collection, exhaled breath analysis, blood draws, and optionally, bronchoscopy to collect lung tissue and fluid samples. During the study, participants will undergo various assessments including disease-specific questionnaires, lung tests, and biological sample collection at King's College London and Guys and St Thomas' NHS Foundation Trust. Researchers will analyze blood samples over six years to identify immune types related to airway diseases and monitor their stability. The study tracks participants annually and at times of clinical changes, with safety and data collection monitored throughout the observation period.

Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung