Actively Recruiting
A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography
Led by Mayo Clinic · Updated on 2025-12-26
20
Participants Needed
1
Research Sites
106 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a prospective case control study to determine the feasibility and utility of myocardial stiffness assessment by cardiac magnetic resonance elastography (MRE) in patients with cardiac amyloidosis.
CONDITIONS
Official Title
A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult age 20 years or older
- Clinically stable without cardiovascular hospitalizations within 2 weeks before enrollment
- Able to provide written informed consent and complete study procedures
- Diagnosed with ATTR cardiac amyloidosis within 10 years prior to screening meeting specified diagnostic criteria
- Diagnosed with AL cardiac amyloidosis within 10 years prior to screening meeting specified diagnostic criteria
You will not qualify if you...
- Unable to consent or complete all study procedures
- Unable to walk for 6 minutes
- Unable to lie flat on back for 30 minutes
- Unable to hold breath for 10 seconds
- Contraindications to MRI such as uncontrolled claustrophobia or presence of cochlear implant or neural stimulator
- Having an implantable cardiac pacemaker or defibrillator
- History of complex congenital heart disease or prosthetic valves in main pulmonary artery or ascending thoracic aorta
- Significant artifacts on prior MRI studies
- Pregnant or breastfeeding women
- Weight equal to or greater than 155 kg
- Any ongoing medical condition or lab abnormalities that could increase risk or interfere with the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
K
Kathy Brown
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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