Study of Heart Muscle Stiffness in Amyloidosis Using Magnetic Resonance Elastography

What this Trial Is About

Researchers are evaluating the feasibility and usefulness of measuring heart muscle stiffness using cardiac magnetic resonance elastography MRE in patients with cardiac amyloidosis. This observational study focuses on adults aged 20 and older who have either transthyretin ATTR or AL cardiac amyloidosis, aiming to better understand this diagnostic method in a clinical setting. The study is sponsored by Mayo Clinic and plans to run until November 2027. Participants will undergo a cardiac MRI that includes both continuous free-breathing and breath-held MRE sequences to assess myocardial stiffness. The study will observe the percentage of subjects able to complete the MRE exam and measure the average stiffness of the heart muscle at baseline. No treatments or interventions beyond the imaging procedure are involved. Throughout the study, participants will complete the MRE exam while researchers monitor their ability to tolerate breath-holding and lying in a supine position. The primary measurements include exam completion rates and myocardial stiffness values. Safety considerations include screening for MRI contraindications and physical ability to participate. The study duration varies by participant, with assessments focused on baseline imaging results.

A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography