Actively Recruiting
Myocardial Stiffness in Amyloidosis by Magnetic Resonance Elastography - AMREloid Study
Led by Mayo Clinic · Updated on 2025-12-26
20
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the feasibility and usefulness of measuring heart muscle stiffness using cardiac magnetic resonance elastography (MRE) in patients with cardiac amyloidosis. This observational study focuses on adults aged 20 and older who have either transthyretin (ATTR) or AL cardiac amyloidosis, aiming to better understand this diagnostic method in a clinical setting. The study is sponsored by Mayo Clinic and plans to run until November 2027. Participants will undergo a cardiac MRI that includes both continuous free-breathing and breath-held MRE sequences to assess myocardial stiffness. The study will observe the percentage of subjects able to complete the MRE exam and measure the average stiffness of the heart muscle at baseline. No treatments or interventions beyond the imaging procedure are involved. Throughout the study, participants will complete the MRE exam while researchers monitor their ability to tolerate breath-holding and lying in a supine position. The primary measurements include exam completion rates and myocardial stiffness values. Safety considerations include screening for MRI contraindications and physical ability to participate. The study duration varies by participant, with assessments focused on baseline imaging results.
CONDITIONS
Brief Title
A Study Of Myocardial Stiffness In Amyloidosis With Magnetic Resonance Elastography
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult aged 20 years or older
- Clinically stable without cardiovascular-related hospitalizations within 2 weeks prior to enrollment
- Able to provide written informed consent and complete study procedures
- Meet criteria for either ATTR cardiac amyloidosis or AL cardiac amyloidosis based on medical records:
- ATTR: Amyloidosis diagnosis within 10 years, with cardiac involvement confirmed by tissue deposits, bone scintigraphy, echocardiography, MRI, or clinical diagnosis
- AL: Amyloidosis diagnosis within 10 years, histopathologic diagnosis with AL protein, and cardiac involvement confirmed by tissue deposits, echocardiography, NT-proBNP levels, MRI, or clinical diagnosis
You will not qualify if you...
- Unable to consent or complete all study procedures
- Unable to walk for 6 minutes
- Unable to lie supine for 30 minutes
- Unable to hold breath for 10 seconds
- Contraindications to MRI (e.g., uncontrolled claustrophobia, cochlear implant, implanted neural stimulator)
- Presence of implantable cardiac pacemaker or defibrillator
- History of complex congenital heart disease or prosthetic valves in main pulmonary artery or ascending thoracic aorta
- Significant MRI artifacts from prior studies
- Pregnant or breastfeeding women
- Weight equal to or greater than 155 kg
- Any ongoing medical condition or laboratory abnormalities that increase risk, interfere with study, or affect results as judged by investigator
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a cardiac MRI with Magnetic Resonance Elastography (MRE) sequences to assess myocardial stiffness.
1 visit (in-person)
Duration - Up to 5 years
Participants are observed following the diagnostic evaluation to monitor clinical status related to amyloidosis.
Visits scheduled as needed for clinical follow-up
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
K
Kathy Brown
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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