Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.
S Ogawa, D W Tank, R Menon...
https://pubmed.ncbi.nlm.nih.gov/1631079/Actively Recruiting
Led by National Institute of Neurological Disorders and Stroke (NINDS) · Updated on 2026-08-07
1100
Participants Needed
1
Research Sites
N/A
Total Duration
Researchers are studying new magnetic resonance imaging MRI techniques and hardware to better understand brain function. This study aims to improve MRI image quality by enhancing spatial resolution and contrast, allowing clearer views of brain anatomy and activity. The research focuses on healthy adult volunteers to develop methods that could later help interpret brain behavior in both normal and abnormal conditions. Participants will undergo MRI scans using advanced machines stronger than those in most hospitals. These scans capture detailed images of brain blood flow and activity while participants perform simple tasks like listening, tapping, moving, watching, or smelling. The study may also include EEG and other physiological recordings to complement MRI data. Scans typically last from 20 minutes to up to 3 hours, with most between 45 and 90 minutes, and will be done annually. Volunteers will be screened through medical history and neurological exams before participating. During the study, participants will have yearly MRI scans to collect detailed brain images. Researchers will track and measure the ability to obtain high-resolution anatomical and functional images, as well as study brain tissue properties and blood flow. The study aims to enhance MRI methods for better brain research, with ongoing monitoring during each yearly visit.
CONDITIONS
Study of New Magnetic Resonance Imaging Methods of the Brain
J
Jeffrey H Duyn, Ph.D.
A
Alan P Koretsky, Ph.D.
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National Institute of Neurological Disorders and Stroke (NINDS)
Lead Sponsor
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Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 3 hours per scan, repeated annually
Participants undergo a yearly MRI scan using advanced imaging machines. During the scan, they may perform simple tasks such as listening, tapping, watching, or smelling to help researchers study brain function.
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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S Ogawa, D W Tank, R Menon...
https://pubmed.ncbi.nlm.nih.gov/1631079/J A Detre, J S Leigh, D S Williams...
https://pubmed.ncbi.nlm.nih.gov/1734182/S Ogawa, T M Lee, A R Kay...
https://pubmed.ncbi.nlm.nih.gov/2124706/National Institute of Neurological Disorders and Stroke (NINDS)
Lead Sponsor