Actively Recruiting
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
Led by Alexion Pharmaceuticals, Inc. · Updated on 2026-04-16
510
Participants Needed
267
Research Sites
329 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this study to evaluate efficacy of ravulizumab compared with placebo on proteinuria reduction and change in eGFR in adult participants with IgAN who are at risk of disease progression.
CONDITIONS
Official Title
Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of IgAN confirmed by kidney biopsy before or during screening for those with eGFR ≥ 30 mL/min/1.73 m2
- For advanced kidney disease cohort, eGFR between 20 and 29 mL/min/1.73 m2 with biopsy within 6 months before or during screening
- Urine protein creatinine ratio (UPCR) ≥ 0.75 g/g or urine protein ≥ 1 g/day based on two 24-hour urine samples during screening
- Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2 at screening
- Stable and maximum allowed or tolerated dose of RASI (ACEI and/or ARB) for at least 3 months before screening with no planned changes through Week 106
- Stable and maximum allowed or tolerated dose of SGLT2I, DEARA, MRA, or ERA for at least 3 months before screening with no planned changes through Week 106
You will not qualify if you...
- Rapid progressive glomerulonephritis with eGFR loss ≥ 50% over 3 months before screening
- Secondary IgAN due to conditions like systemic lupus erythematosus, cirrhosis, or celiac disease (IgAV-N may be allowed)
- Other clinically significant kidney diseases besides IgAN
- Immunosuppressive treatment within 3 months before screening
- Uncontrolled diabetes with HbA1c greater than 8.5%
- Henoch-Schonlein purpura requiring systemic immunosuppressive therapy within 12 months before screening
- History of or planned kidney transplant during the treatment period
- Splenectomy or functional absence of spleen
- History of Neisseria meningitidis infection
- Active bacterial, viral, or fungal infection within 14 days before randomization
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 267 locations
1
Research Site
Alabaster, Alabama, United States, 35007
Actively Recruiting
2
Research Site
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
Research Site
Loma Linda, California, United States, 92354
Actively Recruiting
4
Research Site
Los Angeles, California, United States, 90022
Actively Recruiting
5
Research Site
Los Angeles, California, United States, 90027
Actively Recruiting
6
Research Site
Los Angeles, California, United States, 90095
Actively Recruiting
7
Research Site
Orange, California, United States, 92868
Actively Recruiting
8
Research Site
San Diego, California, United States, 92120
Actively Recruiting
9
Research Site
San Francisco, California, United States, 94143
Actively Recruiting
10
Research Site
Stanford, California, United States, 94305
Actively Recruiting
11
Research Site
Torrance, California, United States, 90502
Actively Recruiting
12
Research Site
Valencia, California, United States, 91355
Actively Recruiting
13
Research Site
Aurora, Colorado, United States, 80045
Actively Recruiting
14
Research Site
Bay Pines, Florida, United States, 33744
Actively Recruiting
15
Research Site
Miami, Florida, United States, 33136
Actively Recruiting
16
Research Site
Orlando, Florida, United States, 32806
Actively Recruiting
17
Research Site
Acworth, Georgia, United States, 30101
Actively Recruiting
18
Research Site
Atlanta, Georgia, United States, 30322
Actively Recruiting
19
Research Site
Lawrenceville, Georgia, United States, 30046
Actively Recruiting
20
Research Site
Iowa City, Iowa, United States, 52242
Actively Recruiting
21
Research Site
New Orleans, Louisiana, United States, 70121
Actively Recruiting
22
Research Site
Shreveport, Louisiana, United States, 71103
Actively Recruiting
23
Research Site
Augusta, Maine, United States, 04330
Actively Recruiting
24
Research Site
Boston, Massachusetts, United States, 02111
Actively Recruiting
25
Research Site
Boston, Massachusetts, United States, 02114
Actively Recruiting
26
Research Site
Boston, Massachusetts, United States, 02115
Actively Recruiting
27
Research Site
Worcester, Massachusetts, United States, 01655
Actively Recruiting
28
Research Site
Minneapolis, Minnesota, United States, 55435
Actively Recruiting
29
Research Site
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
30
Research Site
Kansas City, Missouri, United States, 64111
Actively Recruiting
31
Research Site
North Las Vegas, Nevada, United States, 89086
Actively Recruiting
32
Research Site
Albany, New York, United States, 12208
Actively Recruiting
33
Research Site
East Setauket, New York, United States, 11733
Actively Recruiting
34
Research Site
New York, New York, United States, 10016
Actively Recruiting
35
Research Site
The Bronx, New York, United States, 10468
Actively Recruiting
36
Research Site
Columbus, Ohio, United States, 43210
Actively Recruiting
37
Research Site
Charleston, South Carolina, United States, 29425
Actively Recruiting
38
Research Site
Knoxville, Tennessee, United States, 37920
Actively Recruiting
39
Research Site
Arlington, Texas, United States, 76002
Actively Recruiting
40
Research Site
Houston, Texas, United States, 77030
Actively Recruiting
41
Research Site
Houston, Texas, United States, 77054
Actively Recruiting
42
Research Site
San Antonio, Texas, United States, 78229
Actively Recruiting
43
Research Site
Shenandoah, Texas, United States, 77384
Actively Recruiting
44
Research Site
Temple, Texas, United States, 76508
Withdrawn
45
Research Site
Charlottesville, Virginia, United States, 22908
Actively Recruiting
46
Research Site
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
47
Research Site
Ciudad de Buenos Aires, Argentina, C1015ABO
Actively Recruiting
48
Research Site
Ciudad de Buenos Aires, Argentina, C1425AGC
Actively Recruiting
49
Research Site
Córdoba, Argentina, X5016KET
Actively Recruiting
50
Research Site
La Plata, Argentina, B1902COS
Actively Recruiting
51
Research Site
Rosario, Argentina, 2000
Actively Recruiting
52
Research Site
San Juan Bautista, Argentina, 1888
Withdrawn
53
Research Site
Camperdown, Australia, 2050
Withdrawn
54
Research Site
Canberra, Australia, 2605
Active, Not Recruiting
55
Research Site
Clayton, Australia, 3168
Active, Not Recruiting
56
Research Site
Concord, Australia, 2139
Active, Not Recruiting
57
Research Site
Herston, Australia, 4029
Active, Not Recruiting
58
Research Site
Liverpool, Australia, 2170
Active, Not Recruiting
59
Research Site
Parkville, Australia, 3050
Withdrawn
60
Research Site
Perth, Australia, 6000
Active, Not Recruiting
61
Research Site
Southport, Australia, 4222
Active, Not Recruiting
62
Research Site
St Albans, Australia, 3021
Active, Not Recruiting
63
Research Site
Graz, Austria, 8036
Active, Not Recruiting
64
Research Site
Innsbruck, Austria, 6020
Active, Not Recruiting
65
Research Site
Linz, Austria, 4020
Active, Not Recruiting
66
Research Site
Brussels, Belgium, 1090
Active, Not Recruiting
67
Research Site
Edegem, Belgium, 2650
Terminated
68
Research Site
Leuven, Belgium, 3000
Active, Not Recruiting
69
Research Site
Belo Horizonte, Brazil, 30110-934
Active, Not Recruiting
70
Research Site
Belo Horizonte, Brazil, 30150-221
Active, Not Recruiting
71
Research Site
Botucatu, Brazil, 18618-687
Active, Not Recruiting
72
Research Site
Curitiba, Brazil, 80440-020
Active, Not Recruiting
73
Research Site
Fortaleza, Brazil, 60430-270
Active, Not Recruiting
74
Research Site
Recife, Brazil, 50670-901
Active, Not Recruiting
75
Research Site
Ribeirão Preto, Brazil, 14051-140
Active, Not Recruiting
76
Research Site
São José do Rio Preto, Brazil, 15090-000
Active, Not Recruiting
77
Research Site
São Paulo, Brazil, 04038-002
Active, Not Recruiting
78
Research Site
São Paulo, Brazil, 05403-000
Active, Not Recruiting
79
Research Site
Winnipeg, Manitoba, Canada, R2V 3M3
Actively Recruiting
80
Research Site
Brampton, Ontario, Canada, L6T 5T6
Actively Recruiting
81
Research Site
London, Ontario, Canada, N6A 5W9
Actively Recruiting
82
Research Site
Toronto, Ontario, Canada, M5G 2C4
Actively Recruiting
83
Research Site
Araucania, Chile, 4781151
Active, Not Recruiting
84
Research Site
Providencia, Chile, 7500000
Active, Not Recruiting
85
Research Site
Santiago, Chile, 7500922
Active, Not Recruiting
86
Research Site
Santiago, Chile, 8330034
Active, Not Recruiting
87
Research Site
Valdivia, Chile, 5090146
Active, Not Recruiting
88
Research Site
Baotou, China, 14010
Active, Not Recruiting
89
Research Site
Beijing, China, 100029
Active, Not Recruiting
90
Research Site
Beijing, China, 100034
Active, Not Recruiting
91
Research Site
Beijing, China, 100044
Active, Not Recruiting
92
Research Site
Changsha, China, 410013
Active, Not Recruiting
93
Research Site
Changzhou, China, 272100
Active, Not Recruiting
94
Research Site
Chengdu, China, 610000
Active, Not Recruiting
95
Research Site
Chengdu, China, 610072
Active, Not Recruiting
96
Research Site
Chongqing, China, 400010
Completed
97
Research Site
Guangzhou, China, 510100
Active, Not Recruiting
98
Research Site
Hangzhou, China, 310003
Active, Not Recruiting
99
Research Site
Jinan, China, 250021
Active, Not Recruiting
100
Research Site
Jinhua, China, 321000
Actively Recruiting
101
Research Site
Lanzhou, China, 730000
Active, Not Recruiting
102
Research Site
Luoyang, China, 471000
Active, Not Recruiting
103
Research Site
Nanchang, China, 330006
Active, Not Recruiting
104
Research Site
Nanchang, China, 330008
Active, Not Recruiting
105
Research Site
Nanjing, China, 210009
Active, Not Recruiting
106
Research Site
Nanjing, China, 210011
Active, Not Recruiting
107
Research Site
Nanjing, China, 210029
Active, Not Recruiting
108
Research Site
Ningbo, China, 315010
Active, Not Recruiting
109
Research Site
Qingdao, China, 110016
Active, Not Recruiting
110
Research Site
Shanghai, China, 200025
Active, Not Recruiting
111
Research Site
Shanghai, China, 200040
Actively Recruiting
112
Research Site
Shanghai, China, 200065
Actively Recruiting
113
Research Site
Shenzhen, China, 518036
Active, Not Recruiting
114
Research Site
Shenzhen, China, 518053
Active, Not Recruiting
115
Research Site
Ürümqi, China, 831118
Active, Not Recruiting
116
Research Site
Wuhan, China, 430060
Active, Not Recruiting
117
Research Site
Wuxi, China, 214023
Active, Not Recruiting
118
Research Site
Xi'an, China, 710061
Active, Not Recruiting
119
Research Site
Yantai, China, 264000
Active, Not Recruiting
120
Research Site
Yibin, China, 610500
Active, Not Recruiting
121
Research Site
Yinchuan, China, 750004
Active, Not Recruiting
122
Research Site
Zhengzhou, China, 450052
Active, Not Recruiting
123
Research Site
Zhongshan, China, 528401
Withdrawn
124
Research Site
Nový Jičín, Czechia, 741 01
Active, Not Recruiting
125
Research Site
Prague, Czechia, 128 00
Active, Not Recruiting
126
Research Site
Prague, Czechia, 140 00
Active, Not Recruiting
127
Research Site
Amiens, France, 80054
Active, Not Recruiting
128
Research Site
Bayonne, France, 64100
Actively Recruiting
129
Research Site
Brest, France, 29200
Active, Not Recruiting
130
Research Site
Chambéry, France, 73011
Active, Not Recruiting
131
Research Site
Le Kremlin-Bicêtre, France, 94270
Active, Not Recruiting
132
Research Site
Marseille, France, 13385
Active, Not Recruiting
133
Research Site
Nantes, France, 44093
Active, Not Recruiting
134
Research Site
Paris, France, 75010
Active, Not Recruiting
135
Research Site
Paris, France, 75015
Active, Not Recruiting
136
Research Site
Saint-Priest-en-Jarez, France, 42270
Active, Not Recruiting
137
Research Site
Strasbourg, France, 67091
Active, Not Recruiting
138
Research Site
Toulouse, France, 31059
Active, Not Recruiting
139
Research Site
Aachen, Germany, 52074
Active, Not Recruiting
140
Research Site
Berlin, Germany, 10117
Active, Not Recruiting
141
Research Site
Cologne, Germany, 50937
Actively Recruiting
142
Research Site
Erlangen, Germany, 91054
Active, Not Recruiting
143
Research Site
Essen, Germany, 45122
Active, Not Recruiting
144
Research Site
Greifswald, Germany, 17475
Active, Not Recruiting
145
Research Site
Hanover, Germany, 30625
Active, Not Recruiting
146
Research Site
Konstanz, Germany, 78464
Withdrawn
147
Research Site
Mainz, Germany, 55131
Active, Not Recruiting
148
Research Site
München, Germany, 81377
Active, Not Recruiting
149
Research Site
München, Germany, 81657
Active, Not Recruiting
150
Research Site
Villingen-Schwenningen, Germany, 78052
Terminated
151
Research Site
Athens, Greece, 11527
Active, Not Recruiting
152
Research Site
Athens, Greece, 12462
Active, Not Recruiting
153
Research Site
Heraklion, Greece, 71500
Active, Not Recruiting
154
Research Site
Pátrai, Greece, 26504
Actively Recruiting
155
Research Site
Thessaloniki, Greece, 57010
Active, Not Recruiting
156
Research Site
Hong Kong, Hong Kong, 999077
Active, Not Recruiting
157
Research Site
Hong Kong, Hong Kong
Active, Not Recruiting
158
Research Site
Haifa, Israel, 3109601
Active, Not Recruiting
159
Research Site
Jerusalem, Israel, 91120
Active, Not Recruiting
160
Research Site
Nazareth, Israel, 16100
Active, Not Recruiting
161
Research Site
Petah Tikva, Israel, 49372
Active, Not Recruiting
162
Research Site
Tel Aviv, Israel, 6423906
Active, Not Recruiting
163
Research Site
Agrigento, Italy, 92100
Active, Not Recruiting
164
Research Site
Bologna, Italy, 40138
Active, Not Recruiting
165
Research Site
Brescia, Italy, 25123
Active, Not Recruiting
166
Research Site
Cagliari, Italy, 09121
Active, Not Recruiting
167
Research Site
Florence, Italy, 50134
Active, Not Recruiting
168
Research Site
Milan, Italy, 20122
Active, Not Recruiting
169
Research Site
Milan, Italy, 20132
Active, Not Recruiting
170
Research Site
Padova, Italy, 35128
Active, Not Recruiting
171
Research Site
Parma, Italy, 43126
Active, Not Recruiting
172
Research Site
Torino, Italy, 10154
Active, Not Recruiting
173
Research Site
Torrette, Italy, 60126
Active, Not Recruiting
174
Research Site
Verona, Italy, 37126
Active, Not Recruiting
175
Research Site
Bunkyō City, Japan, 113-8431
Active, Not Recruiting
176
Research Site
Chiba, Japan, 260-8677
Active, Not Recruiting
177
Research Site
Chiba, Japan, 260-8712
Active, Not Recruiting
178
Research Site
Fukuoka, Japan, 815-8555
Active, Not Recruiting
179
Research Site
Kamakura, Japan, 247-8533
Active, Not Recruiting
180
Research Site
Kasugai-shi, Japan, 486-8510
Active, Not Recruiting
181
Research Site
Kitakyushu-shi, Japan, 802-8555
Active, Not Recruiting
182
Research Site
Kobe, Japan, 650-0047
Active, Not Recruiting
183
Research Site
Matsumoto-shi, Japan, 390-8621
Active, Not Recruiting
184
Research Site
Matsuyama, Japan, 790-8524
Active, Not Recruiting
185
Research Site
Nagoya, Japan, 466-8650
Active, Not Recruiting
186
Research Site
Osaka, Japan, 534-0021
Active, Not Recruiting
187
Research Site
Osaka, Japan, 545-8586
Active, Not Recruiting
188
Research Site
Sapporo, Japan, 060-8604
Active, Not Recruiting
189
Research Site
Urayasu-shi, Japan, 279-0021
Active, Not Recruiting
190
Research Site
Ipoh, Malaysia, 30990
Active, Not Recruiting
191
Research Site
Johor Bahru, Malaysia, 80100
Active, Not Recruiting
192
Research Site
Kuala Lumpur, Malaysia, 59100
Active, Not Recruiting
193
Research Site
Seremban, Malaysia, 70300
Active, Not Recruiting
194
Research Site
Taiping, Malaysia, 34000
Withdrawn
195
Research Site
Amsterdam, Netherlands, 1105 AZ
Active, Not Recruiting
196
Research Site
Rotterdam, Netherlands, 3045 PM
Active, Not Recruiting
197
Research Site
Bialystok, Poland, 15-276
Active, Not Recruiting
198
Research Site
Bialystok, Poland, 15-540
Active, Not Recruiting
199
Research Site
Krakow, Poland, 31-513
Active, Not Recruiting
200
Research Site
Lodz, Poland, 92-213
Active, Not Recruiting
201
Research Site
Lublin, Poland, 20-090
Active, Not Recruiting
202
Research Site
Olsztyn, Poland, 10-561
Active, Not Recruiting
203
Research Site
Poznan, Poland, 60-355
Active, Not Recruiting
204
Research Site
Szczecin, Poland, 70-111
Active, Not Recruiting
205
Research Site
Warsaw, Poland, 02-006
Active, Not Recruiting
206
Research Site
Warsaw, Poland, 02-507
Active, Not Recruiting
207
Research Site
Dammam, Saudi Arabia, 31444
Active, Not Recruiting
208
Research Site
Jeddah, Saudi Arabia, 21499
Active, Not Recruiting
209
Research Site
Riyadh, Saudi Arabia, 11211
Active, Not Recruiting
210
Research Site
Riyadh, Saudi Arabia, 12231
Active, Not Recruiting
211
Research Site
Banská Bystrica, Slovakia, 974 01
Active, Not Recruiting
212
Research Site
Martin, Slovakia, 03659
Active, Not Recruiting
213
Research Site
Anyang-si, South Korea, 14068
Active, Not Recruiting
214
Research Site
Busan, South Korea, 49241
Active, Not Recruiting
215
Research Site
Deagu, South Korea, 41944
Active, Not Recruiting
216
Research Site
Gwangju, South Korea, 61469
Active, Not Recruiting
217
Research Site
Gyeonggi-do, South Korea, 13620
Active, Not Recruiting
218
Research Site
Seoul, South Korea, 03080
Active, Not Recruiting
219
Research Site
Seoul, South Korea, 03722
Active, Not Recruiting
220
Research Site
Seoul, South Korea, 05278
Active, Not Recruiting
221
Research Site
Suwon, South Korea, 16499
Active, Not Recruiting
222
Research Site
A Coruña, Spain, 15006
Active, Not Recruiting
223
Research Site
Alcalá de Henares, Spain, 28805
Active, Not Recruiting
224
Research Site
Lleida, Spain, 25198
Completed
225
Research Site
Madrid, Spain, 28031
Active, Not Recruiting
226
Research Site
Madrid, Spain, 28040
Completed
227
Research Site
Madrid, Spain, 28046
Withdrawn
228
Research Site
Málaga, Spain, 29010
Active, Not Recruiting
229
Research Site
Murcia, Spain, 30120
Active, Not Recruiting
230
Research Site
Oviedo, Spain, 33011
Active, Not Recruiting
231
Research Site
Seville, Spain, 41013
Active, Not Recruiting
232
Research Site
Tarragona, Spain, 09-43005
Active, Not Recruiting
233
Research Site
Zaragoza, Spain, 50009
Active, Not Recruiting
234
Research Site
Kaohsiung City, Taiwan, 80756
Active, Not Recruiting
235
Research Site
Kaohsiung City, Taiwan, 81362
Active, Not Recruiting
236
Research Site
Kaohsiung City, Taiwan, 833401
Active, Not Recruiting
237
Research Site
New Taipei City, Taiwan, 220
Active, Not Recruiting
238
Research Site
New Taipei City, Taiwan, 23561
Active, Not Recruiting
239
Research Site
Taichung, Taiwan, 40705
Active, Not Recruiting
240
Research Site
Taichung, Taiwan
Active, Not Recruiting
241
Research Site
Tainan, Taiwan, 70403
Active, Not Recruiting
242
Research Site
Taipei, Taiwan, 10002
Active, Not Recruiting
243
Research Site
Taoyuan, Taiwan, 333
Active, Not Recruiting
244
Research Site
Bangkok, Thailand, 10330
Active, Not Recruiting
245
Research Site
Bangkok, Thailand, 10400
Active, Not Recruiting
246
Research Site
Bangkok, Thailand, 10700
Active, Not Recruiting
247
Research Site
Chiang Mai, Thailand, 50200
Active, Not Recruiting
248
Research Site
Khon Kaen, Thailand, 40002
Active, Not Recruiting
249
Research Site
Ankara, Turkey (Türkiye), 06560
Active, Not Recruiting
250
Research Site
Bursa, Turkey (Türkiye), 16059
Active, Not Recruiting
251
Research Site
Istanbul, Turkey (Türkiye), 34098
Active, Not Recruiting
252
Research Site
Istanbul, Turkey (Türkiye), 34452
Active, Not Recruiting
253
Research Site
Kahramanmaraş, Turkey (Türkiye), 46100
Withdrawn
254
Research Site
Kayseri, Turkey (Türkiye), 38039
Active, Not Recruiting
255
Research Site
Kocaeli, Turkey (Türkiye), 41380
Active, Not Recruiting
256
Research Site
Konya, Turkey (Türkiye), 42080
Active, Not Recruiting
257
Research Site
Pamukkale, Turkey (Türkiye), 20070
Withdrawn
258
Research Site
Cambridge, United Kingdom, CB2 0QQ
Active, Not Recruiting
259
Research Site
Doncaster, United Kingdom, DN2 5LT
Active, Not Recruiting
260
Research Site
Dundee, United Kingdom, DD1 9SY
Withdrawn
261
Research Site
Leicester, United Kingdom, Le5 4PW
Active, Not Recruiting
262
Research Site
London, United Kingdom, E1 1BB
Active, Not Recruiting
263
Research Site
London, United Kingdom, SE1 9RT
Withdrawn
264
Research Site
Manchester, United Kingdom, M13 9WL
Active, Not Recruiting
265
Research Site
Reading, United Kingdom, RG1 5AN
Active, Not Recruiting
266
Research Site
Salford, United Kingdom, M6 8HD
Withdrawn
267
Research Site
Stevenage, United Kingdom, SG1 4AB
Active, Not Recruiting
Research Team
A
Alexion Pharmaceuticals, Inc. (Sponsor)
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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