Actively Recruiting
Use of a Remote Voice Analysis Tool for Diagnosing and Monitoring Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Led by Mayo Clinic · Updated on 2026-05-27
40
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to assess the use of a remote voice analysis tool for diagnosing and managing myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers want to understand how well this voice-based tool can help identify and monitor ME/CFS by analyzing voice signatures. The study is observational and focuses on evaluating the feasibility of this method. Participants will record their voices using a smartphone application called Visible, while wearing the Visible Armband 2.0. They will create 5 to 10-minute recordings that include counting, vowel sounds, changing speaking speed, and repeating words every two weeks for a total of 12 weeks. These voice samples will be collected to study how voice patterns relate to ME/CFS symptoms and severity. During the study, participants will complete questionnaires and provide voice recordings regularly. Researchers will measure the feasibility of using the Mayo Speech Test to screen, monitor, and assess the severity of ME/CFS over 12 weeks. The study will track how well participants can use the technology and how accurately voice data reflects their condition. Participation will last for about 12 weeks with ongoing monitoring.
CONDITIONS
Brief Title
A Study Of Remote Voice Analysis Tool For Diagnosing And Monitoring ME/CFS
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) verified by an ME/CFS specialist
- Ability to complete study questionnaires and provide voice samples using a smartphone application
- Consistent access to a smartphone or tablet with iOS or Android operating systems, or a laptop
You will not qualify if you...
- No diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); "Chronic Fatigue Syndrome" not verified by an ME/CFS specialist
- Lack of consistent access to a smartphone or tablet with iOS or Android operating systems, or laptop
- Known dementia or other neurodegenerative disorder prominently affecting cognition or speech patterns outside of ME/CFS
- Known history of voice disorder either primary or secondary to neuromuscular or other pathology outside of ME/CFS
- Known clinically significant heart failure or greater than moderate pulmonary hypertension
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or remote)
Duration - 12 weeks
Participants provide voice recordings every 2 weeks using a smartphone application while wearing a Visible Armband 2.0 to help diagnose and monitor ME/CFS.
Voice recordings every 2 weeks
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
K
Katie Cruz
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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