Actively Recruiting
Therapeutic Evaluation of Steroids in IgA Nephropathy Global Post-Trial Observational Cohort Study
Led by The George Institute · Updated on 2025-02-11
366
Participants Needed
58
Research Sites
N/A
Total Duration
On this page
Sponsors
T
The George Institute
Lead Sponsor
P
Peking University Institute of Nephrology
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research focuses on people who took part in the original TESTING study, which looked at the long-term effects of taking oral methylprednisolone, a steroid, for 6 to 9 months. The study aims to see how this treatment affects the risk of developing end stage kidney disease (ESKD) over time. Researchers are particularly interested in how different doses (full vs reduced), ethnicity (Chinese vs other), and kidney function levels influence these outcomes. Participants in this extended study are those who were part of the original TESTING trial, are still alive, have not developed kidney failure needing dialysis, and have not withdrawn consent. This follow-up study will observe these individuals for up to five years, monitoring their health after the steroid treatment course. The study does not involve new treatments but tracks the long-term impact of the prior steroid use. During the study, researchers will collect information on kidney health and disease progression, focusing on key outcomes such as the development of ESKD. Data will be gathered through ongoing follow-up visits and assessments over an average period of one year, with possible longer observation if funding permits. The goal is to understand the lasting effects of the steroid treatment and whether lower doses offer similar benefits with fewer risks.
CONDITIONS
Brief Title
TESTING -ON Post-Trial ObservatioNal Cohort Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Only participants who were randomised into the TESTING trial
You will not qualify if you...
- Participants who have reached kidney failure requiring maintenance dialysis or kidney transplantation during the TESTING trial
- Participants who died during the TESTING trial
- Participants who had withdrawn their consent during the TESTING trial
- Participants who are unable to provide consent for some other reason
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 5 years or longer if funding allows
Participants who completed the original TESTING trial and meet eligibility criteria are followed to assess the long-term effects of a 6-9 month course of oral methylprednisolone on kidney outcomes.
Periodic visits for up to 5 years
Trial Site Locations
Total: 58 locations
1
Nepean Hospital
Kingswood, New South Wales, Australia, 2747
Actively Recruiting
2
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
3
Royal Adelaide Hospital
Adelaide, South Australia, Australia, 5000
Actively Recruiting
4
University of Calgary/Alberta Health Services
Calgary, Alberta, Canada, T2R 0X7
Not Yet Recruiting
5
University of Alberta Hospitals
Edmonton, Alberta, Canada, T6G 2B7
Actively Recruiting
6
St Pauls Hospital
Vancouver, British Columbia, Canada, V6Z 1Y6
Not Yet Recruiting
7
St. Joseph's Healthcare
Hamiliton, Ontario, Canada, L8N 4A6
Not Yet Recruiting
8
London Health Sciences Centre
London, Ontario, Canada
Completed
9
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
10
Toronto General Hospital,
Toronto, Ontario, Canada, M5G 2N2
Not Yet Recruiting
11
Hôpital Maisonneuve-Rosemont
Montreal, Quebec, Canada, H1T 2M4
Not Yet Recruiting
12
Chinese PLA General Hospital (301 Hospital)
Beijing, Beijing Municipality, China
Actively Recruiting
13
The First Affiliated Hospital, Sun Yat-Sen University
Guangzhou, Guangdong, China, 510080
Not Yet Recruiting
14
Guangdong Provincial People's Hospital, Guangzhou
Guangzhou, Guangdong, China
Active, Not Recruiting
15
Peking University Shenzhen Hospital
Shenzhen, Guangdong, China, 518036
Actively Recruiting
16
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050005
Actively Recruiting
17
The Third Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050051
Actively Recruiting
18
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, Henan, China, 471003
Actively Recruiting
19
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Not Yet Recruiting
20
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China, 430022
Not Yet Recruiting
21
Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430022
Actively Recruiting
22
Renmin Hospital, Wuhan University
Wuhan, Hubei, China, 430060
Not Yet Recruiting
23
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology,
Baotou, Inner Mongolia, China, 014010
Not Yet Recruiting
24
Inner Mongolia People's Hospital
Hohhot, Inner Mongolia, China, 010017
Actively Recruiting
25
The First Affiliated Hospital with Nanjing Medical University
Nanjing, Jiangsu, China, 210029
Not Yet Recruiting
26
Jilin Province FAW General Hospital [Jilin University Fourth Hospital]
Changchun, Jilin, China, 130011
Not Yet Recruiting
27
he First Affiliated Hospital of Dalian Medical University, Dalian
Dalian, Liaoning, China, 116011
Not Yet Recruiting
28
Shengjing Hospital Of China Medical University
Shengyang, Liaoning, China
Actively Recruiting
29
Qilu Hospital of Shandong University
Jinan, Shandong, China, 250012
Not Yet Recruiting
30
The First Affiliated Hospital of Shangdong First Medical University,Shangdong Provincial Qianfoshin
Jinan, Shandong, China, 250014
Actively Recruiting
31
Shandong Provincial Hospital
Jinan, Shandong, China, 250021
Not Yet Recruiting
32
Jinan Military General Hospital
Jinan, Shandong, China
Not Yet Recruiting
33
The Second Hospital of Shanxi Medical University, Taiyuan
Taiyuan, Shanxi, China, 030001
Not Yet Recruiting
34
West China Hospital of Sichuan University
Chengdu, Sichuan, China, 610041
Actively Recruiting
35
Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital
Chengdu, Sichuan, China, 610072
Not Yet Recruiting
36
The First Affiliated Hospital, Zhejiang University of Medicine
Hangzhou, Zhejiang, China, 310003
Not Yet Recruiting
37
Hangzhou Hospital of Traditional Chinese Medicine,
Hangzhou, Zhejiang, China
Actively Recruiting
38
Ningbo Urology & Nephrology Hospital
Ningbo, Zhejiang, China
Not Yet Recruiting
39
Zhejiang Provincial People's Hospital
Sangzhou, Zhejiang, China
Actively Recruiting
40
Beijing Anzhen Hospital, Capital Medical University
Beijing, China, 100029
Not Yet Recruiting
41
Peking University First Hospital
Beijing, China, 100034
Actively Recruiting
42
Peking University People's Hospital
Beijing, China, 100035
Not Yet Recruiting
43
Peking University Third Hospital
Beijing, China
Not Yet Recruiting
44
XinQiao Hospital, Third Military Medical University
Chongqing, China, 400037
Actively Recruiting
45
Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, China, 200001
Not Yet Recruiting
46
Ruijin Hospital, Shanghai Jiaotong University, School of Medicine
Shanghai, China, 200025
Not Yet Recruiting
47
Princess Margaret Hospital
Kowloon, Hong Kong
Completed
48
Osmania General Hospital
Hyderabad, Andhra Pradesh, India, 500012
Actively Recruiting
49
Nizams Institute of Medical Sciences
Hyderabad, Andhra Pradesh, India, 500082
Not Yet Recruiting
50
Calicut Medical College
Kozhikode, Kerala, India, 673008,
Actively Recruiting
51
Post Graduate Institue of Medical Education and Reasearch
Chandigarh, Punjab, India, 160 012
Actively Recruiting
52
Madras Medical College
Chen, Tamil Nadu, India, 600037
Actively Recruiting
53
Hospital Sultanah Aminah
Johor Bahru, Johor, Malaysia, 80100
Actively Recruiting
54
Hospital Kuala Lumpur
Kuala Lumpur, Kulala Lumpur, Malaysia, 50586
Actively Recruiting
55
Hospital Tuanku Jaafar Seremban
Seremban, Negri Seremban, Malaysia, 70300
Actively Recruiting
56
Hospital Raja Permaisuri Bainun
Ipoh, Perak, Malaysia, 30990
Actively Recruiting
57
Hospital Umum Sarawak
Kuching, Samarahan, Malaysia, 93586
Actively Recruiting
58
University Malaysia Medical Centre
Kuala Lumpur, Malaysia, 59100
Actively Recruiting
Research Team
R
Rebecca Anderson
H
Helen Monaghan
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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