Actively Recruiting
Adding Urea to the Final Dialysis Fluid
Led by University of California, San Francisco · Updated on 2026-02-12
20
Participants Needed
1
Research Sites
145 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
At times patients with advanced renal failure present with severe hyperkalemia or acidosis and very high serum blood urea nitrogen (BUN) concentrations. These patients cannot be dialyzed aggressively as the lowering of serum BUN may results in disequilibrium syndrome but on the other hand they need aggressive dialysis in order to lower their serum potassium or fix their severe acidosis. If one is able to add urea to the dialysis fluid, one can prevent the rapid lowering of serum BUN and osmolality at the same time as doing aggressive dialysis to lower serum potassium and/or fix the metabolic acidosis.
CONDITIONS
Official Title
Adding Urea to the Final Dialysis Fluid
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Serum urea level greater than 120
- Serum potassium level greater than 5.5 or serum CO2 level less than 15 or need for aggressive dialysis due to toxic ingestion
- Need for dialysis treatment
- Age 18 years or older
You will not qualify if you...
- Pediatric patients
- Patients needing continuous renal replacement therapy (CRRT)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zuckerberg San Francisco General Hospital
San Francisco, California, United States, 94110
Actively Recruiting
Research Team
R
Ramin Sam, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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