Determining Distal Outflow Tract Function in Open Angle Glaucoma as a Predictive Test for the Success of Ab Interno Trabeculectomy

What this Trial Is About

Researchers are studying open angle glaucoma and pseudoexfoliation glaucoma to develop a non-invasive test called trabeculopuncture. This test aims to evaluate the function of the distal outflow tract and predict how successful ab interno trabeculectomy surgery might be for patients. The study is sponsored by Wuerzburg University Hospital and seeks to personalize treatment by selecting the most suitable surgical procedure based on this predictive test. Participants will undergo trabeculopuncture using a Nd:YAG laser to create four punctures along the nasal trabecular meshwork before having ab interno trabeculectomy surgery. The study involves measuring eye pressure and outflow function before and after the laser test, as well as at multiple time points after surgery, including two hours, one week, four weeks, and three months postoperatively. During the study, participants will have intraocular pressure (IOP) and outflow facility measured at the specified time points to assess the effect of trabeculopuncture and surgery. Researchers will evaluate surgical success three months after the procedure. The study requires ongoing monitoring and testing during these periods to track eye pressure changes and the function of the eye's fluid drainage system, with total participation lasting at least three months after surgery.

Trabeculopuncture as Predictive Test for the Success of Ab Interno Trabeculectomy