Testing Combined Brain Stimulation and Therapy for Adults with Obsessive-Compulsive Disorder A Study of rTMS with Exposure and Response Prevention or Supportive Therapy

What this Trial Is About

Researchers are evaluating how adults with Obsessive-Compulsive Disorder OCD respond to repetitive Transcranial Magnetic Stimulation rTMS combined with psychotherapy. The study compares two types of therapy given with rTMS Exposure and Response Prevention ERP Therapy and supportive therapy ST. The goal is to understand treatment effects and predict responses using biobehavioral data collected from wearable devices and smartphones, along with brain imaging. Participants will receive rTMS targeted to specific brain areas five days a week for six weeks. Alongside rTMS, they will attend either ERP or supportive therapy sessions twice weekly, conducted virtually during rTMS treatments. The study includes baseline assessments, brain scans, and continuous collection of behavioral and physiological data using a Fitbit device and daily self-reports via smartphone. The study lasts 16 weeks, beginning with initial assessments and brain imaging. During weeks 2 to 7, participants undergo treatment with rTMS and therapy while weekly OCD symptom assessments are conducted. After treatment, brain imaging and final evaluations occur at week 8. Participants then stop data collection and complete a follow-up assessment at week 16 to evaluate longer-term outcomes. The main outcome measured is change in OCD symptoms using the Yale-Brown Obsessive-Compulsive Scale YBOCS.

Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder