Actively Recruiting
Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Led by Adam Frank · Updated on 2025-10-27
48
Participants Needed
1
Research Sites
142 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will test how people with OCD respond to a type of noninvasive brain stimulation, repetitive Transcranial Magnetic Stimulation (rTMS), when it is combined with psychotherapy. Participants will either engage in Exposure and Response Prevention (ERP) Therapy or supportive therapy (ST) while receiving rTMS. Biobehavioral data from wearable devices and smartphones will be collected to better predict treatment responses. Participants will also undergo repeat resting state functional Magnetic Resonance Imaging (rsfMRI) in order to assess neural predictors and mechanisms of treatment response.
CONDITIONS
Official Title
Transcranial Magnetic Stimulation and Psychotherapy for Treating Obsessive-Compulsive Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of Obsessive-Compulsive Disorder (OCD) based on DSM-5 criteria
- Live in Southern California and able to attend in-person rTMS sessions 5 days per week for 6 weeks
- Completed at least ten previous sessions of Exposure and Response Prevention (ERP) therapy
- Currently take or have previously tried Serotonin Reuptake Inhibitor (SRI) medication for OCD
- Willing to keep psychotropic medication levels stable during the 16-week study period
You will not qualify if you...
- Primary psychiatric diagnosis other than OCD
- Active substance use disorder
- Active suicidality
- Active psychosis
- History of seizures
- Severe neurological impairment
- Pregnant or planning to become pregnant
- Previously received a course of repetitive Transcranial Magnetic Stimulation (rTMS)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Southern California Health Sciences Campus
Los Angeles, California, United States, 90033
Actively Recruiting
Research Team
U
USC Frank OCD Lab
CONTACT
E
Emma Garland, BA
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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