Actively Recruiting
UK Heart Failure With Preserved Ejection Fraction
Led by Manchester University NHS Foundation Trust · Updated on 2025-05-06
10000
Participants Needed
26
Research Sites
764 weeks
Total Duration
On this page
Sponsors
M
Manchester University NHS Foundation Trust
Lead Sponsor
P
Pumping Marvellous Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
CONDITIONS
Official Title
UK Heart Failure With Preserved Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Diagnosis of HFpEF by a cardiologist, primary care physician, or heart failure nurse with heart failure expertise
- Natriuretic peptide levels measured
You will not qualify if you...
- Left ventricular ejection fraction below 40% at screening or any previous measurement
- Known infiltrative cardiomyopathy such as amyloid, sarcoid, lymphoma, or endomyocardial fibrosis
- Known active myocarditis, constrictive pericarditis, or cardiac tamponade
- Known genetic or obstructive hypertrophic cardiomyopathy
- Known arrhythmogenic right ventricular cardiomyopathy
- Known severe primary valvular heart disease
- Known idiopathic, heritable, or drug-induced pulmonary arterial hypertension
- History of heart transplantation or ventricular assist device
- Complex congenital heart disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 26 locations
1
Cwm Taf Morgannwg University Health Board
Abercynon, United Kingdom, CF31 1RQ
Actively Recruiting
2
Buckinghamshire Healthcare NHS Trust
Aylesbury, United Kingdom, HP21 8AL
Actively Recruiting
3
University Hospitals Birmingham NHS Foundation Trust
Birmingham, United Kingdom, B15 2GW
Actively Recruiting
4
Broomfield Hospital
Chelmsford, United Kingdom, CM1 7ET
Actively Recruiting
5
NHS Tayside
Dundee, United Kingdom, DD2 1UB
Actively Recruiting
6
Glasgow Royal Infirmary
Glasgow, United Kingdom, G4 0SF
Actively Recruiting
7
West Suffolk NHS Foundation Trust
Ipswich, United Kingdom, IP33 2QZ
Actively Recruiting
8
Kettering General Hospital
Kettering, United Kingdom, NN16 8UZ
Actively Recruiting
9
Leeds Teaching Hospitals NHS Trust
Leeds, United Kingdom, LS1 3EX
Actively Recruiting
10
University Hospitals of Leicester NHS Foundation Trust
Leicester, United Kingdom, LE5 4PW
Actively Recruiting
11
Barnet Hospital
London, United Kingdom, EN5 3DJ
Actively Recruiting
12
Guys and St. Thomas' NHS Foundation Trust
London, United Kingdom, SE1 7EH
Actively Recruiting
13
Imperial College Healthcare NHS Trust
London, United Kingdom, W2 1NY
Actively Recruiting
14
Manchester University NHS Foundation trust
Manchester, United Kingdom, M13 9WU
Actively Recruiting
15
The James Cook University Hospital
Middlesbrough, United Kingdom, TS4 3BW
Actively Recruiting
16
Northumbria Healthcare NHS Foundation Trust
Newcastle upon Tyne, United Kingdom, NE23 6NZ
Actively Recruiting
17
Norfolk & Norwich University Hospitals NHS Foundation Trust
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
18
George Eliot Hospital
Nuneaton, United Kingdom, CV10 7DJ
Actively Recruiting
19
North West Anglia NHS Foundation Trust
Peterborough, United Kingdom, PE3 9GZ
Actively Recruiting
20
University Hospitals Dorset NHS Foundation Trust
Poole, United Kingdom, BH15 2JB
Actively Recruiting
21
Betsi Cadwaldr University Health Board
Rhyl, United Kingdom, LL18 5UJ
Actively Recruiting
22
Salisbury NHS Foundation Trust
Salisbury, United Kingdom, SP2 8BJ
Actively Recruiting
23
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, United Kingdom, S5 7AU
Actively Recruiting
24
University Hospital of North Tees
Stockton-on-Tees, United Kingdom, TS19 8PE
Actively Recruiting
25
South Tyneside & Sunderland NHS Foundation Trust
Sunderland, United Kingdom, SR4 7TP
Actively Recruiting
26
Southend University Hospital
Westcliff-on-Sea, United Kingdom, SS0 0RY
Actively Recruiting
Research Team
F
Fardad Soltani, MBChB MRCP
CONTACT
L
Lucy Priestner
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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