Occlusion Pressure at 100 Msec, Expiratory Time Constant, Mechanical Stress Power, Ventilatory Ratio, and C20/Cdyn in Predicting Outcomes in Moderately Severe ARDS Patients on Mechanical Ventilation

What this Trial Is About

Researchers are evaluating several ventilatory parameters to predict outcomes in patients with moderately severe Acute Respiratory Distress Syndrome (ARDS) who require mechanical ventilation. This observational study focuses on measures such as occlusion pressure at 100 milliseconds (Pocc), expiratory time constant (TCe), mechanical stress power, ventilatory ratio, and the C20/Cdyn ratio. The aim is to better understand how these factors relate to patient survival and clinical outcomes during mechanical ventilation in ARDS. The study observes patients from the day of intubation, collecting data over the first three days. Parameters including Pocc, TCe, C20/C index, ventilatory ratio, mechanical stress power, and the PaO2/FiO2 ratio are recorded daily. Researchers also track clinical outcomes such as the need for vasopressors, prone positioning, paralysis, changes in ventilator modes, duration of ventilation, length of ICU and hospital stay, major adverse kidney events, and 30-day survival and disability. Participants will be assessed through routine monitoring of ventilatory and clinical parameters, with data collected in a de-identified manner for analysis. The primary outcome is survival or mortality up to 90 days from enrollment. Secondary outcomes include major adverse kidney events and lengths of ICU and hospital stay. Statistical analyses will explore the predictive value of these ventilatory measures for patient outcomes. The total participant involvement covers initial mechanical ventilation days and follow-up assessments up to 90 days.

Ventilatory Parameters in Predicting Outcomes in ARDS Patients