High-Dose Vitamin D Supplementation During Pregnancy to Prevent Early Childhood Asthma and Wheezing

What this Trial Is About

Researchers are studying whether taking higher doses of vitamin D during pregnancy can help prevent early childhood asthma or persistent wheezing in children up to 3 years old. The study targets pregnant women with higher levels of certain fatty acids in their blood. It also looks at other child health outcomes such as respiratory infections, eczema, allergies, bone fractures, development, mental health, and growth, following children until age 6 for some outcomes. Pregnant women are randomly assigned to take either a high dose of vitamin D 3200 IU daily or a placebo capsule containing olive oil, starting between week 22 and 26 of pregnancy and continuing until one week after delivery. All participants also receive the recommended standard dose of 400 IU vitamin D. Blood samples will be collected for genetic and metabolic studies. The children will be followed for 3 years, with plans for extended follow-up until age 6 after the study is unblinded. Participants will be monitored through parent-reported symptoms, medical records, and registrations of medication use and hospital visits for their children. Researchers will assess lung and allergy symptoms, infections, developmental milestones, and mental health among other measures. The study includes regular data collection during the 3-year follow-up period and ongoing evaluation of health outcomes to better understand the impact of prenatal vitamin D supplementation on early childhood health.

VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma