Actively Recruiting
A Randomized Comparison Between White Light Endoscopy and Bright Narrow Band Imaging in Detecting Right Sided Colonic Polyps in Asymptomatic Adults Undergoing Screening Colonoscopy
Led by Western Sydney Local Health District · Updated on 2025-03-30
600
Participants Needed
1
Research Sites
26 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating whether narrow band imaging (NBI) or white light endoscopy (WLE) is better at detecting polyps in the right side of the colon during screening colonoscopy. This study focuses on average-risk, asymptomatic adults over 50 years old undergoing screening to improve early detection of colorectal adenomas, which can help prevent colorectal cancer. The study recognizes that some polyps, especially flat ones, are harder to spot and that newer imaging techniques like NBI may provide clearer mucosal details compared to standard white light. The study uses a randomized crossover design where participants receive both imaging methods during the same colonoscopy. One group will have the white light endoscopy first followed by bright narrow band imaging (B-NBI), while the other group will have B-NBI first followed by WLE using the same high-definition colonoscope. This allows comparison of polyp detection rates between the two methods in the right colon. Participants will undergo a screening colonoscopy with sequential evaluations by both imaging techniques. Researchers will measure the rate of polyp detection on the right side of the colon with each method and specifically assess detection of sessile serrated polyps (SSPs). The study includes a single evaluation day per participant. Safety monitoring and follow-up details are not specified. The total participation time corresponds to the colonoscopy procedure and immediate evaluation.
CONDITIONS
Brief Title
White Light vs Narrow Band Imagingin the Diagnosis of Right Sided Colonic Polyps in Asymptomatic Subjects Undergoing Screening Colonoscopy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Asymptomatic subjects undergoing screening colonoscopy
- Age 50 years or older
- Average risk subjects without personal history of inflammatory bowel disease, colon adenoma, or colon cancer
- No family history of familial adenomatous polyposis, familial non-polyposis syndrome, or colorectal cancer in first-degree relatives
- No colonoscopy performed in the past 5 years
- Ability to provide written consent to participate in the trial
You will not qualify if you...
- Unable to provide consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a screening colonoscopy using either white light endoscopy or bright narrow band imaging to detect right sided colonic polyps.
1 procedure visit (in-person)
Trial Site Locations
Total: 1 location
1
Westmead Hospital
Sydney, New South Wales, Australia, 2145
Actively Recruiting
Research Team
M
Michael Bourke, MBBS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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