Brain Activity Changes During Natural and Stimulated Menstrual Cycles in Healthy Women Aged 25 to 35 Undergoing Ovarian Stimulation

What this Trial Is About

Researchers are investigating how the brains activity changes during different phases of the ovarian stimulation cycle compared to the natural menstrual cycle in young, healthy women. This study focuses on understanding the impact of externally administered hormones on brain dynamics, an area not previously explored, to provide important insights about the safety and neurophysiological effects of ovarian stimulation used in fertility treatments. Participants will undergo assessments during both a natural menstrual cycle and an ovarian stimulation cycle. These include six resting-state functional MRI scans taken at specific cycle phases basal day 2-3, around ovulation, and mid-luteal phase. Additional monitoring includes blood tests for hormone levels and vaginal ultrasounds for follicular counts. The first visit includes a buccal swab for whole genome sequencing. Throughout the study, participants will be evaluated eight times with hormone tests, ultrasounds, and MRI imaging at key cycle points. Researchers will measure brain activity patterns using fMRI and track hormonal fluctuations Estradiol, LH, FSH, Progesterone. The total study duration varies depending on menstrual cycle length, with continuous monitoring to assess brain connectivity and neurodynamics safely.

Whole-Brain Dynamics in the Natural Menstrual Cycle vs. an Ovarian Stimulated Cycle: Impact of Hormonal Fluctuations on Healthy Women Undergoing Ovarian Stimulation