Conflict-of-interest guidelines for a multicenter clinical trial of treatment after coronary-artery bypass-graft surgery.
B Healy, L Campeau, R Gray...
https://pubmed.ncbi.nlm.nih.gov/2784541Completed
Phase 3
Age: 18Years - 75Years
All Genders
ID00000463
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-04-14
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To determine the relative effectiveness of moderate versus more aggressive lipid lowering, and of low dose anticoagulation versus placebo, in delaying saphenous vein coronary bypass graft atherosclerosis and preventing occlusion of saphenous grafts of patients with saphenous vein coronary bypass grafts placed 1 to 11 years previously.
CONDITIONS
Official Title
Post Coronary Artery Bypass Graft (CABG) Study
Who Can Participate
Age: 18Years - 75Years
All Genders
Eligibility Criteria
You may qualify if you...
Men and women between 1 and 11 years post-CABG. Patients had two completely independent saphenous vein grafts that were patent. Patients had an LDL-cholesterol between 130 and 175 with plasma triglycerides below 300 mg/dl.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
PREVENTION
Number of Arms
0
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Published Research Related To This Trial
Intense dietary counseling lowers LDL cholesterol in the recruitment phase of a clinical trial of men who had coronary artery bypass grafts.
D M Shenberger, R J Helgren, J R Peters...
https://pubmed.ncbi.nlm.nih.gov/1556345The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts.
Post Coronary Artery Bypass Graft Trial Investigators
https://pubmed.ncbi.nlm.nih.gov/8992351Prevention of atherosclerosis in coronary-artery bypass grafts.
V Fuster, D A Vorchheimer
https://pubmed.ncbi.nlm.nih.gov/8988902Comparison of preoperative characteristics of men and women undergoing coronary artery bypass grafting (the Post Coronary Artery Bypass Graft [CABG] Biobehavioral Study).
S M Czajkowski, M Terrin, R Lindquist...
https://pubmed.ncbi.nlm.nih.gov/9114757An application of the Zucker-Wittes modified ratio estimate statistic in the Post Coronary Artery Bypass Graft (CABG) clinical trial.
P L Canner, B Thompson, G L Knatterud...
https://pubmed.ncbi.nlm.nih.gov/9257071Effects of aggressive cholesterol lowering and low-dose anticoagulation on clinical and angiographic outcomes in patients with diabetes: the Post Coronary Artery Bypass Graft Trial.
B J Hoogwerf, A Waness, M Cressman...
https://pubmed.ncbi.nlm.nih.gov/10342818Safety of coronary arteriography in clinically stable patients following coronary bypass surgery. Post CABG Clinical Trial Investigators.
F L Gobel, W J Stewart, L Campeau...
https://pubmed.ncbi.nlm.nih.gov/9863740Is aggressive cholesterol control justified? Review of the post-coronary artery bypass graft trial.
D B Hunninghake
https://pubmed.ncbi.nlm.nih.gov/9860374Long-term effects on clinical outcomes of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation in the post coronary artery bypass graft trial. Post CABG Investigators.
G L Knatterud, Y Rosenberg, L Campeau...
https://pubmed.ncbi.nlm.nih.gov/10889125