Completed
Phase 3
Age: 65Years - 100Years
All Genders
ID00000556
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2016-03-25
N/A
Participants Needed
N/A
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
To compare two standard treatment strategies for atrial fibrillation: ventricular rate control and anticoagulation vs. rhythm control and anticoagulation.
CONDITIONS
Official Title
Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM)
Who Can Participate
Age: 65Years - 100Years
All Genders
Eligibility Criteria
You may qualify if you...
Elderly men and women with atrial fibrillation and other risk factors for stroke.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Site Locations not provided
Location information for this trial is currently unavailable.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
N/A
Allocation
RANDOMIZED
Model
N/A
Primary Purpose
TREATMENT
Number of Arms
0
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Published Research Related To This Trial
The AFFIRM trial: main trial and substudies-what can We expect?
D G Wyse
https://pubmed.ncbi.nlm.nih.gov/10590505Management of atrial fibrillation: the need for AFFIRMative action. AFFIRM investigators. Atrial Fibrillation Follow-up Investigation of Rhythm Management.
A L Waldo
https://pubmed.ncbi.nlm.nih.gov/10498142Baseline characteristics of patients with atrial fibrillation: the AFFIRM Study.
AFFIRM Investigators. Atrial Fibrillation Follow-up Investigation of Rhythm Management
https://pubmed.ncbi.nlm.nih.gov/12075254Frequency of symptomatic atrial fibrillation in patients enrolled in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Andrew E Epstein, Humberto Vidaillet, H Leon Greene...
https://pubmed.ncbi.nlm.nih.gov/12139289A comparison of rate control and rhythm control in patients with atrial fibrillation.
D G Wyse, A L Waldo, J P DiMarco...
https://pubmed.ncbi.nlm.nih.gov/12466506Maintenance of sinus rhythm in patients with atrial fibrillation: an AFFIRM substudy of the first antiarrhythmic drug.
AFFIRM First Antiarrhythmic Drug Substudy Investigators
https://pubmed.ncbi.nlm.nih.gov/12849654Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study.
Scott D Corley, Andrew E Epstein, John P DiMarco...
https://pubmed.ncbi.nlm.nih.gov/15007003Analysis of cause-specific mortality in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.
Jonathan S Steinberg, Ara Sadaniantz, Jack Kron...
https://pubmed.ncbi.nlm.nih.gov/15051639Relation between achieved heart rate and outcomes in patients with atrial fibrillation (from the Atrial Fibrillation Follow-up Investigation of Rhythm Management [AFFIRM] Study).
Howard A Cooper, Dennis A Bloomfield, David E Bush...
https://pubmed.ncbi.nlm.nih.gov/15135698