Status:
COMPLETED
Bone Mineral Density in Women With Major Depression
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Involutional Depression
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bon...
Detailed Description
Osteoporosis is a condition that is underdiagnosed and undertreated, and often goes unnoticed until a fragility fracture occurs after many years of progressive loss of bone quality. Risk factors for o...
Eligibility Criteria
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INCLUSION CRITERIA:
A history of current or past major depression of at least four months duration, or a history of two or more brief depressive episodes will be the primary criterion for inclusion.
Patients with Bipolar Disorder will be eligible if they meet the depressive episode criterion.
No specific inclusion criteria are set for normal volunteers.
EXCLUSION CRITERIA:
DEPRESSED SUBJECTS:
Pregnant women will not be eligible to participate.
Known medical causes of osteoporosis, other than depression.
Current or past history of eating disorders, or schizophrenia, as per DSM-IV.
Chronic use of oral or parenteral steroids (daily use for 3 months or longer).
HEALTHY SUBJECTS:
Pregnant women will not be eligible to participate.
Known medical causes of osteoporosis.
Any history of DSM-IV diagnosis, including depression, eating disorders, and alcohol or drug abuse.
History or current evidence of any significant clinical or laboratory abnormalities.
Key Trial Info
Start Date :
April 6 1994
Trial Type :
OBSERVATIONAL
End Date :
January 19 2007
Estimated Enrollment :
585 Patients enrolled
Trial Details
Trial ID
NCT00001413
Start Date
April 6 1994
End Date
January 19 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892