Bone density of the radius, spine, and proximal femur in osteoporosis.
R B Mazess, H Barden, M Ettinger...
https://pubmed.ncbi.nlm.nih.gov/3213603Completed
Age: 18Years +
All Genders
Healthy Volunteers
ID00001413
Bone Mineral Density in Patients With Major Depression With Melancholic and Atypical Features: Relation to Stress-System Neurohormonal Function
Led by National Institute of Mental Health (NIMH) · Updated on 2017-07-02
585
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to examine calcium absorption and bone mineral density in women with depression. Research indicates that pre-menopausal women with depression have significantly lower bone mineral density (BMD) than pre-menopausal women without depression. Although the mechanisms of BMD loss are unclear, researchers believe that individuals with depression have impaired calcium absorption. However, it is unknown whether the abnormal absorption is a result of depression or a side effect of the drugs used to treat it. This study will compare calcium absorption in women with depression and in healthy women without depression. Participants in this study will be given two non-radioactive calcium isotopes. One can be taken by mouth and the other must be injected. Participants will have the level of isotopes in their urine measured to estimate true fractional calcium absorption (TFCA). Participants may also have a dual X-ray absorptiometry (DEXA) scan to measure total body adiposity and lean body mass.
CONDITIONS
Official Title
Bone Mineral Density in Women With Major Depression
Who Can Participate
Age: 18Years +
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
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INCLUSION CRITERIA:
A history of current or past major depression of at least four months duration, or a history of two or more brief depressive episodes will be the primary criterion for inclusion.
Patients with Bipolar Disorder will be eligible if they meet the depressive episode criterion.
No specific inclusion criteria are set for normal volunteers.
EXCLUSION CRITERIA:
DEPRESSED SUBJECTS:
Pregnant women will not be eligible to participate.
Known medical causes of osteoporosis, other than depression.
Current or past history of eating disorders, or schizophrenia, as per DSM-IV.
Chronic use of oral or parenteral steroids (daily use for 3 months or longer).
HEALTHY SUBJECTS:
Pregnant women will not be eligible to participate.
Known medical causes of osteoporosis.
Any history of DSM-IV diagnosis, including depression, eating disorders, and alcohol or drug abuse.
History or current evidence of any significant clinical or laboratory abnormalities.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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