Active, Not Recruiting
A Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MK-4082 in Healthy Overweight/Obese Participants
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-28
120
Participants Needed
5
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are looking for new weight loss medicines for people with higher body weight. The study medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a study medicine to people with a health condition, researchers first do studies to find a safe dose level (amount) of the study medicine that can be used in future studies. The goals of this study are to learn about: * The safety of MK-4082 and if people tolerate it * What happens to different MK-4082 dose levels in a person's body over time
CONDITIONS
Brief Title
A Clinical Study of MK-4082 in Healthy Overweight Participants (MK-4082-002)
Who Can Participate
Eligibility Criteria
You may qualify if you...
The main inclusion criteria include but are not limited to the following:
- Is in good health
- Has body mass index (BMI) between 25 and 40 kg/m^2, inclusive. Participants must weigh at least 60 kg
You will not qualify if you...
The main exclusion criteria include but are not limited to the following:
- has a history of previous surgical treatment for obesity (bariatric surgery, gastric banding, etc.) or any other gastrointestinal (GI) surgery that may induce malabsorption, history of bowel resection >20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss (including LAP-BAND®), as well as clinically significant GI disorders (eg, peptic ulcers, severe gastroesophageal reflux disease)
- has an individual or family history of medullary thyroid carcinoma or multiple endocrine neoplasia 2
Trial Site Locations
Total: 5 locations
1
Anaheim Clinical Trials ( Site 0005)
Anaheim, California, United States, 92801
Status Unknown
2
ProSciento Inc. ( Site 0002)
Chula Vista, California, United States, 91911
Status Unknown
3
QPS-MRA, LLC ( Site 0003)
South Miami, Florida, United States, 33143
Status Unknown
4
Bio-Kinetic Clinical Applications, LLD dba QPS-MO ( Site 0004)
Springfield, Missouri, United States, 65802
Status Unknown
5
Hassman Research Institute Marlton Site ( Site 0006)
Marlton, New Jersey, United States, 08053
Status Unknown
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
BASIC_SCIENCE
Number of Arms
5
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