Status:
COMPLETED
Study of the Hypothalmic-Pituitary-Adrenal (HPA) Axis and Its Role in Major Depression
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Fatigue Syndrome, Chronic
Healthy
Eligibility:
All Genders
Brief Summary
Major depression represents a major public health problem worldwide and in the U.S. Fifteen percent of the U.S. population has depression at some point in life (40 million individuals). The condition ...
Detailed Description
Major depression represents a major public health problem worldwide and in the U.S. Fifteen percent of the U.S. population has depression at some point in life (40 million individuals), with a female ...
Eligibility Criteria
Patients with primary affective disorder (major depression), chronic fatigue syndrome, and control subjects.
Psychiatric diagnosis will be made by means of the Structured Clinical Diagnosis for DSM-III-R (SCID), performed by senior experienced clinicians.
Exclusion Criteria:
Subjects on chronic medications, which can not be washed out in one month.
Subjects with any serious medical illnesses which have been excluded.
Women who are pregnant, trying to become pregnant or sexually active and not using effective contraception.
Patients with HIV-1 infection.
Patients on chronic lithium therapy.
Subjects unable to discontinue alcohol, tobacco, or illegal drugs.
Key Trial Info
Start Date :
January 1 1995
Trial Type :
OBSERVATIONAL
End Date :
May 1 2000
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT00001479
Start Date
January 1 1995
End Date
May 1 2000
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892