Status:
COMPLETED
Dynamics of Leptin and Endocrine Function
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy
Involutional Depression
Eligibility:
All Genders
Brief Summary
This is a study investigating the hormones and substances important to the stress response. The hormone that is most directly responsible for stress response is called corticotropin-releasing hormone ...
Detailed Description
Our group has tested the hypothesis that the molecules involved in the neurobiology of the stress response are key elements in the pathophysiology, treatment, and medical consequences of major depress...
Eligibility Criteria
Depressed patients must have a history of past major depression of at least four months duration, or a history of two or more briefer episodes. Must be overweight.
Must not need a hospital admission as part of their treatment.
Overweight normal volunteers.
No subjects on chronic medication which cannot be washed out for one month.
No subjects with any serious medical illness.
No women who are pregnant, trying to become pregnant, or sexually active and not using effective contraception.
No patients with HIV infection.
No subjects who cannot discontinue use of alcohol/tobacco.
Key Trial Info
Start Date :
March 1 1996
Trial Type :
OBSERVATIONAL
End Date :
June 1 2002
Estimated Enrollment :
230 Patients enrolled
Trial Details
Trial ID
NCT00001543
Start Date
March 1 1996
End Date
June 1 2002
Last Update
March 4 2008
Active Locations (1)
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1
National Institute of Mental Health (NIMH)
Bethesda, Maryland, United States, 20892