Brain mapping with functional MR imaging: comparison of gradient-echo--based exogenous and endogenous contrast techniques.
V S Mattay, D R Weinberger, F A Barrios...
https://pubmed.ncbi.nlm.nih.gov/7862963Completed
Age: 18Years - 80Years
All Genders
ID00001619
Magnetic Resonance at 1.5 and 3 Tesla
Led by National Heart, Lung, and Blood Institute (NHLBI) · Updated on 2017-07-02
497
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Magnetic resonance imaging (MRI) is a diagnostic tool that creates high quality images of the human body without the use of X-ray (radiation). MRI uses different levels of magnetic fields to create images of the body and organs. Occasionally, researchers will give patients undergoing a MRI an injection of a substance called gadolinium. Gadolinium works by brightening areas of the magnetic resonance image, thereby improving the contrast. In this study researchers will use magnetic resonance imaging and contrast substances, like gadolinium, on normal volunteers in order to evaluate different aspects of its performance. Information gathered from this study may be used to develop more specific research studies involving MRI.
CONDITIONS
Official Title
Magnetic Resonance Imaging at Different Levels of Magnetic Intensity
Who Can Participate
Age: 18Years - 80Years
All Genders
Eligibility Criteria
You may qualify if you...
- INCLUSION CRITERIA:
Any normal volunteer greater than or equal to 18 who is capable of giving informed consent.
EXCLUSION CRITERIA:
A subject will be excluded if he/she has a contraindication to MR scanning such as:
- Brain aneurysm clip
- Implanted neural stimulator
- Implanted cardiac pacemaker or defibrillator
- Cochlear or ear implant
- Ocular foreign body (e.g. metal shavings)
- Insulin pump
- Pregnant women (when uncertain, subject will undergo urine or blood testing).
- Claustrophobia
- Any condition in the Principal Investigator's judgement which present unnecessary risk
EXCLUSION CRITERIA FOR GADOLINIUM ENHANCED STUDIES:
- Lactating Women
- Renal or hepatic disease
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892
Status Unknown
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How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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Published Research Related To This Trial
Tolerance data of Gd-DTPA: a review.
H P Niendorf, J C Dinger, J Haustein...
https://pubmed.ncbi.nlm.nih.gov/1889423Measurement of relative cerebral blood volume changes with visual stimulation by 'double-dose' gadopentetate-dimeglumine-enhanced dynamic magnetic resonance imaging.
J A Frank, V S Mattay, J Duyn...
https://pubmed.ncbi.nlm.nih.gov/7928216