Acute Exposure to Diesel: Prolonged Effects on Inflammation and Vasculature

What this Trial Is About

Researchers are investigating the impact of short-term exposure to diesel exhaust fumes on inflammation and blood vessel function in healthy adults. This randomized, double-blind, crossover study aims to understand how brief diesel exposure may affect arterial stiffness, vascular function, and inflammatory markers related to atherosclerosis. Diesel exhaust is a common urban pollutant linked to cardiovascular and respiratory diseases, but the mechanisms and effects of acute exposure remain unclear. Participants will attend two sessions spaced four weeks apart, during which they will be exposed for two hours to either controlled diesel exhaust fumes or filtered air. Measurements will be taken before exposure, immediately after, and 24 hours later. These include tests of endothelial function using flow mediated dilation, arterial stiffness via pulse wave velocity and augmentation index, heart rate variability to assess sympathetic activity, and blood tests for inflammatory and fibrinolytic markers like C-reactive protein, fibrinogen, protein C, and protein S. During the study, participants will undergo various evaluations such as ultrasound scans, blood pressure assessments, continuous electrocardiographic monitoring, and blood sampling. They will be asked to avoid alcohol, caffeine, smoking, and medication affecting the cardiovascular system. The study monitors changes over 24 hours post-exposure to assess prolonged effects. Total participation includes two exposure visits and follow-up measurements to evaluate vascular and inflammatory responses to diesel fumes.

Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature