Actively Recruiting
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature
Led by University of Athens · Updated on 2019-09-24
40
Participants Needed
2
Research Sites
626 weeks
Total Duration
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AI-Summary
What this Trial Is About
Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). C reactive protein (CRP), fibrinogen, protein C levels and protein S activity will be also measured. Heart rate variability and standard deviation of normal to normal intervals R-R intervals (SDNN) will be used to assess sympathetic activity. Measurements were assessed before, 2 and 24 hours after diesel exposure.
CONDITIONS
Official Title
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy subjects aged 18 to 60 years
You will not qualify if you...
- Chronic diseases
- Cardiovascular diseases
- Respiratory diseases
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
1st Cardiology Department, Hippokration General Hospital
Athens, Attica, Greece, 11528
Actively Recruiting
2
Evangelos Oikonomou
Athens, Please Select, Greece, 17122
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
2
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