Actively Recruiting
Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation: Evaluation of Congestion at Hospital Discharge for Acute Heart Failure with Altered or Moderately Altered Ejection Fraction
Led by Central Hospital, Nancy, France · Updated on 2023-06-05
200
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying patients with acute heart failure who have reduced ejection fraction and are hospitalized for worsening heart failure. The study aims to identify markers of congestion—such as clinical signs, biological data, and ultrasound findings—at the time of hospital discharge that could be linked to the risk of death or rehospitalization within three months after leaving the hospital. Participants will undergo clinical exams focused on congestion, various Doppler ultrasounds of the heart and other organs, blood sample collection for biological tests and storage, and complete quality of life questionnaires. These evaluations take place before hospital discharge. Follow-up includes telephone interviews and quality of life assessments at 3, 12, and 24 months after discharge. During the study, participants will have clinical exams, ultrasounds, blood tests, and questionnaires before discharge, followed by phone interviews at set intervals to monitor their condition. Researchers will measure outcomes such as rates of death, rehospitalization, intravenous diuretic treatments, heart function class, kidney function, and quality of life over 24 months. This monitoring helps assess markers linked to heart failure outcomes over time.
CONDITIONS
Brief Title
Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients hospitalized for acute heart failure
- Patients with reduced ejection fraction less than 40% or between 40% and 50%
- Patients ready to be discharged from hospital for acute heart failure
- Age 18 years or older
- Patients who have received full information about the study and signed informed consent
- Patients covered by a social security scheme
You will not qualify if you...
- Patients with other serious illnesses limiting life expectancy to 3 months or less
- Patients on dialysis or with very low kidney function (glomerular filtration rate less than 15 ml/min/m2)
- History of lung surgery such as lobectomy or pneumonectomy
- Severe lung or pleural diseases preventing reliable lung ultrasound
- Pregnant, breastfeeding, or recently giving birth
- Adults under legal protection or unable to consent
- People deprived of liberty by judicial or administrative order
- Persons receiving psychiatric care under specific public health laws
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to hospital discharge
Participants undergo clinical examination centered on congestion, multiple Doppler ultrasounds, liver elastography, and blood sample collection before hospital discharge.
1 visit (in-person)
Duration - 24 months after hospital discharge
Participants are followed up through telephone interviews and quality of life questionnaires at 3, 12, and 24 months after hospital discharge.
Telephone interviews and questionnaires at 3, 12, and 24 months
Trial Site Locations
Total: 1 location
1
CHRU de Nancy
Vandœuvre-lès-Nancy, France, 54500
Actively Recruiting
Research Team
N
Nicolas GIRERD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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