Registry Study on Acute Myocarditis Clinical, Imaging, Biological, and Genetic Features with Long-Term Prognosis

What this Trial Is About

Researchers are conducting the AMPHIBIA study, an observational cohort focusing on patients hospitalized with acute myocarditis, an inflammatory disease of the heart muscle. This study aims to describe the clinical, biological, imaging, genetic, and histologic features of these patients and how these relate to their long-term prognosis. The study includes both retrospective and prospective analysis, covering patients from 2006 up to 2041 to better understand this complex condition and its outcomes. Patients hospitalized with acute myocarditis will have their clinical, biological, etiological, echocardiographic, cardiac magnetic resonance imaging, genetic for prospective patients, and anatomopathological data collected and analyzed. The registry will include up to 400 patients in the retrospective cohort and 1000 patients in the prospective cohort over 20 years. This comprehensive data collection will support research into the diseases diagnosis, prognosis, and underlying mechanisms. Participants will undergo various assessments including clinical evaluations, imaging scans, biological tests, and genetic analyses as appropriate. Researchers will monitor major cardiac events over one year as the primary outcome and track long-term outcomes such as death, heart transplant, arrhythmias, heart failure, and other cardiac events for up to 20 years. This extensive follow-up aims to provide a detailed understanding of acute myocarditis and its progression over time.

Acute Myocarditis Registry With Prognostic, Histologic, Immunologic, Biological, Imaging and Clinical Assessment