Personalized and Adaptive Treatment Strategies for Veterans with PTSD Using Sequenced Cognitive Processing and Prolonged Exposure Therapies

What this Trial Is About

Researchers are evaluating different treatment strategies for veterans with posttraumatic stress disorder PTSD who do not respond well to their first PTSD treatment or who do not regularly complete homework assignments between sessions. The goal is to find the best way to match the right type and amount of treatment to each individual veteran. This study uses a Hybrid Experimental Design to test various therapist-delivered and digital interventions to determine the optimal combination and sequence of evidence-based treatments. The study involves multiple groups where veterans who do not respond early to Cognitive Processing Therapy CPT may switch to Prolonged Exposure PE or modular versions of CPT or PE, while early responders may continue or step down to self-managed CPT or PE using companion mobile apps. Text message prompts are sent between sessions to encourage homework completion. Treatments are delivered in routine care settings for veterans. Participants will undergo assessments at baseline, 10 weeks, 20 weeks, and 9 months, including the Posttraumatic Stress Disorder Checklist PCL-5 and other questionnaires to measure depression, suicide risk, quality of life, and psychosocial functioning. Researchers will monitor how treatments are completed and their effects over time. The study aims to optimize treatment response by personalizing care for veterans with PTSD over several months of follow-up.

Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)