Actively Recruiting
Changing the Treatment Course: Clinical Trial of Sequenced Interventions to Optimize Treatment for Veterans With PTSD
Led by The University of Texas Health Science Center at San Antonio · Updated on 2025-12-19
302
Participants Needed
4
Research Sites
12 weeks
Total Duration
On this page
Sponsors
T
The University of Texas Health Science Center at San Antonio
Lead Sponsor
U
United States Department of Defense
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating different treatment strategies for veterans with posttraumatic stress disorder (PTSD) who do not respond well to their first PTSD treatment or who do not regularly complete homework assignments between sessions. The goal is to find the best way to match the right type and amount of treatment to each individual veteran. This study uses a Hybrid Experimental Design to test various therapist-delivered and digital interventions to determine the optimal combination and sequence of evidence-based treatments. The study involves multiple groups where veterans who do not respond early to Cognitive Processing Therapy (CPT) may switch to Prolonged Exposure (PE) or modular versions of CPT or PE, while early responders may continue or step down to self-managed CPT or PE using companion mobile apps. Text message prompts are sent between sessions to encourage homework completion. Treatments are delivered in routine care settings for veterans. Participants will undergo assessments at baseline, 10 weeks, 20 weeks, and 9 months, including the Posttraumatic Stress Disorder Checklist (PCL-5) and other questionnaires to measure depression, suicide risk, quality of life, and psychosocial functioning. Researchers will monitor how treatments are completed and their effects over time. The study aims to optimize treatment response by personalizing care for veterans with PTSD over several months of follow-up.
CONDITIONS
Brief Title
Adaptive Decision-making And Personalized Treatment for PTSD (ADAPT-PTSD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Veterans eligible for Prolonged Exposure and Cognitive Processing Therapy at the participating PTSD clinic
- At least 18 years or older
- Score 31 or higher on the PTSD Checklist (PCL-5) related to a traumatic event
- Own a mobile device that can be used for therapy companion apps (PE Coach or CPT Coach)
You will not qualify if you...
- Acute suicide risk requiring clinical intervention
- Need for detoxification
- Unmanaged psychosis or bipolar disorder
- Severe cognitive impairment that makes adherence to the study unlikely
- Current or past 12-month engagement in Prolonged Exposure or Cognitive Processing Therapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 9 months
Participants receive therapist-delivered and digital interventions including Cognitive Processing Therapy, Prolonged Exposure Therapy, modular versions of these therapies, or step-down self-managed treatments depending on their response status and randomization group. Treatment is adaptive and sequenced to optimize outcomes for PTSD.
Multiple visits scheduled over the course of treatment depending on therapy type and response
Duration - Up to 9 months post-treatment start
Participants are monitored at multiple time points to assess PTSD symptoms and other health outcomes after treatment completion.
Visits at 10 weeks, 20 weeks, and 9 months for outcome assessments
Trial Site Locations
Total: 4 locations
1
Augusta VA
Augusta, Georgia, United States, 30904
Actively Recruiting
2
Ann Arbor VA
Ann Arbor, Michigan, United States, 48105
Actively Recruiting
3
Battle Creek VA
Battle Creek, Michigan, United States, 49037
Not Yet Recruiting
4
Salt Lake City VA
Salt Lake City, Utah, United States, 84148
Actively Recruiting
Research Team
S
Stefanie LoSavio, PhD
R
Rebecca Sripada, PhD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
8
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