Actively Recruiting
Adherence to Medication in Patients With Acute Decompensated Heart Failure: a Cross-sectional Study at the Emergency Department
Led by Universität des Saarlandes · Updated on 2024-06-20
100
Participants Needed
1
Research Sites
8 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating medication adherence in patients with acute decompensated heart failure (AHF) who visit the emergency department. The study focuses on measuring adherence directly using a precise method involving liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS/MS), considered the gold standard for adherence measurement. It also aims to explore patient-related factors such as anxiety, depression, social support, and dementia that might affect adherence. Participants in this observational study have chronic heart failure and require intravenous diuretics. They must have been on stable heart failure medication for more than two weeks and show signs of volume overload and elevated natriuretic peptides. The study collects adherence data at a single time point during the emergency visit, along with questionnaire responses to identify factors influencing medication use. During the study visit, researchers measure drug levels in body fluids to assess adherence and gather information from questionnaires about mental health and social support. The primary outcome is medication adherence measured cross-sectionally on one day. Secondary outcomes include the impact of anxiety, depression, social support, and dementia on adherence. Participation involves a single assessment during the emergency department visit, with no long-term follow-up described.
CONDITIONS
Brief Title
Adherence to Medication in Patients With Acute Decompensated Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Known chronic heart failure regardless of ejection fraction
- Requirement of intravenous diuretics as outpatient or inpatient
- Stable heart failure medication for more than 2 weeks
- At least one sign of volume overload such as peripheral edema, jugular venous distension, pulmonary rales, ascites, or pulmonary venous congestion on chest X-ray
- Elevated natriuretic peptides (nt-pro-BNP ≥ 125 pg/ml)
You will not qualify if you...
- Unable to provide written informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo assessment to directly measure adherence to heart failure medication and evaluation of patient-related factors impacting adherence.
1 visit (in-person)
Duration - Ongoing
Participants who undergo routine care are observed to understand adherence patterns and related factors over time.
No additional study visits required
Trial Site Locations
Total: 1 location
1
Department of Internal Medicine III, Cardiology, Angiology and Intensive Care Medicine, University Hospital Saarland, Saarland University
Homburg, Germany, 66421
Actively Recruiting
Research Team
F
Felix Mahfoud, Professor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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