Actively Recruiting
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
Led by Medical University Innsbruck · Updated on 2025-08-22
700
Participants Needed
1
Research Sites
228 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine whether a non-invasive coronary assessment strategy using photon-counting detector computed tomography (PCD-CT) is non-inferior to invasive coronary angiography (ICA) for evaluating coronary artery disease (CAD) prior to transcatheter aortic valve replacement (TAVR) in patients with severe aortic stenosis.
CONDITIONS
Official Title
Assessment of Coronary Artery Disease Before Transcatheter Aortic Valve Replacement: A Randomized, Multicenter, Non-Inferiority Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Severe aortic valve stenosis with indication for intervention according to European Society of Cardiology guidelines
- Candidate for transcatheter aortic valve replacement (TAVR)
- Provided written informed consent
You will not qualify if you...
- Cardiogenic shock at presentation (emergency TAVR indication)
- Severe renal impairment with estimated glomerular filtration rate below 30 mL/min/1.73 m²
- Life expectancy less than 1 year due to severe non-cardiac disease such as cancer
- Pregnancy
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Medical University of Innsbruck
Innsbruck, Austria, 6020
Actively Recruiting
Research Team
S
Sebastian J Reinstadler, MD, PhD
CONTACT
I
Ivan Lechner, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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