Actively Recruiting
Assessment Metabolic Flexibility by Indirect Calorimetry and Circulating Metabolic Parameters in Middle-aged Individuals: The Nutritional Impact of Cheese From Extensive and Intensive Farming
Led by University of Cagliari · Updated on 2023-08-30
105
Participants Needed
1
Research Sites
177 weeks
Total Duration
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AI-Summary
What this Trial Is About
Researchers are evaluating how consuming meat and dairy products from different farming methods affects metabolic health in healthy adults aged 45 to 65 years. This age range is linked to changes in metabolism and body fat. The study focuses on key markers like the gene expression of the transcription factor PPAR-b1 in white blood cells, fatty acid metabolism, and the endocannabinoid system. It also examines metabolic flexibility through exercise testing and measures body composition. Participants will take part in a double-blind, randomized, controlled crossover trial involving two types of pecorino cheese: "kent'erbas" from extensive farming and "industrial" pecorino from intensive farming. Each participant will consume 350 grams per week of one cheese type for 4 weeks, followed by an 8-week washout period without cheese consumption. Then, they will switch to the other cheese type for another 4 weeks. Blood samples will be collected at the end of each period to analyze metabolic changes. Throughout the study, participants will maintain their usual lifestyle and diet. Researchers will gather medical history, anthropometric measurements, and blood samples for detailed analysis. Body composition will be assessed by bioimpedance and waist measurements, while metabolic flexibility will be tested using indirect calorimetry during exercise. The main outcome is the change in plasma levels of DHA and acylethanolamides, with secondary outcomes assessing respiratory quotient changes. The total study duration includes treatment, washout, and crossover phases.
CONDITIONS
Brief Title
Assessment Metabolic Flexibility in Middle-aged Individuals: The Nutritional Impact of Cheese Consumption
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 45 to 65 years of age
- Body mass index (BMI) less than 27
- Waist-to-hip ratio less than 0.85 for females and less than 0.98 for males
You will not qualify if you...
- Presence of metabolic diseases
- Participation in competitive physical activities
- Being vegan or vegetarian
- Allergies or intolerances to the foods studied in this trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 4 weeks per treatment period with an 8-week washout between
Participants consume 350g/week of either "kent'erbas" pecorino from extensive farming or "industrial" pecorino from intensive farming for 4 weeks, then switch to the other type after an 8-week washout period.
Blood samples collected at the end of each 4-week treatment period and after the washout period
Trial Site Locations
Total: 1 location
1
University of Cagliari
Monserrato, Cagliari, Italy, 09042
Actively Recruiting
Research Team
S
Sebastiano Banni
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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